CHEBI:76133 - droxicam

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name droxicam
ChEBI ID CHEBI:76133
Definition An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respectively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C16H11N3O5S
Net Charge 0
Average Mass 357.34100
Monoisotopic Mass 357.042
InChI InChI=1S/C16H11N3O5S/c1-18-13-14(10-6-2-3-7-11(10)25(18,22)23)24-16(21)19(15(13)20)12-8-4-5-9-17-12/h2-9H,1H3
InChIKey OEHFRZLKGRKFAS-UHFFFAOYSA-N
SMILES CN1c2c(oc(=O)n(-c3ccccn3)c2=O)-c2ccccc2S1(=O)=O
Roles Classification
Biological Role(s): hepatotoxic agent
A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.
cyclooxygenase 1 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing droxicam (CHEBI:76133) has functional parent piroxicam (CHEBI:8249)
droxicam (CHEBI:76133) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
droxicam (CHEBI:76133) has role hepatotoxic agent (CHEBI:50908)
droxicam (CHEBI:76133) has role non-narcotic analgesic (CHEBI:35481)
droxicam (CHEBI:76133) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
droxicam (CHEBI:76133) has role platelet aggregation inhibitor (CHEBI:50427)
droxicam (CHEBI:76133) has role prodrug (CHEBI:50266)
droxicam (CHEBI:76133) is a organic heterotricyclic compound (CHEBI:26979)
droxicam (CHEBI:76133) is a pyridines (CHEBI:26421)
IUPAC Name
5-methyl-3-(pyridin-2-yl)-2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
INNs Sources
droxicam KEGG DRUG
droxicam WHO MedNet
droxicam WHO MedNet
droxicamum ChemIDplus
Database Links Databases
970 DrugCentral
D07267 KEGG DRUG
Droxicam Wikipedia
US4563452 Patent
US4797482 Patent
View more database links
Registry Numbers Types Sources
6006252 Reaxys Registry Number Reaxys
90101-16-9 CAS Registry Number ChemIDplus
90101-16-9 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
12093490 PubMed citation Europe PMC
1365484 PubMed citation Europe PMC
1365486 PubMed citation Europe PMC
1365487 PubMed citation Europe PMC
1365489 PubMed citation Europe PMC
1365490 PubMed citation Europe PMC
1365491 PubMed citation Europe PMC
1487550 PubMed citation Europe PMC
1507922 PubMed citation Europe PMC
1507923 PubMed citation Europe PMC
1507924 PubMed citation Europe PMC
1545609 PubMed citation Europe PMC
23656309 PubMed citation Europe PMC
2778095 PubMed citation Europe PMC
3110512 PubMed citation Europe PMC
3221746 PubMed citation Europe PMC
3278945 PubMed citation Europe PMC
3489870 PubMed citation Europe PMC
3762266 PubMed citation Europe PMC
8489815 PubMed citation Europe PMC
8492964 PubMed citation Europe PMC
8616003 PubMed citation Europe PMC
8656732 PubMed citation Europe PMC
8983932 PubMed citation Europe PMC
Last Modified
22 February 2017