CHEBI:7601 - nizatidine

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ChEBI Name nizatidine
ChEBI ID CHEBI:7601
Definition A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C12H21N5O2S2
Net Charge 0
Average Mass 331.45700
Monoisotopic Mass 331.114
InChI InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3
InChIKey SGXXNSQHWDMGGP-UHFFFAOYSA-N
SMILES CNC(NCCSCc1csc(CN(C)C)n1)=C[N+]([O-])=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): H2-receptor antagonist
H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine.
cholinergic drug
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
Application(s): anti-ulcer drug
One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
H2-receptor antagonist
H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine.
cholinergic drug
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
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ChEBI Ontology
Outgoing nizatidine (CHEBI:7601) has role anti-ulcer drug (CHEBI:49201)
nizatidine (CHEBI:7601) has role cholinergic drug (CHEBI:38323)
nizatidine (CHEBI:7601) has role H2-receptor antagonist (CHEBI:37961)
nizatidine (CHEBI:7601) is a 1,3-thiazoles (CHEBI:38418)
nizatidine (CHEBI:7601) is a C-nitro compound (CHEBI:35716)
nizatidine (CHEBI:7601) is a carboxamidine (CHEBI:35359)
nizatidine (CHEBI:7601) is a organic sulfide (CHEBI:16385)
nizatidine (CHEBI:7601) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-{2-[({2-[(dimethylamino)methyl]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}-Nʼ-methyl-2-nitroethene-1,1-diamine
INNs Sources
nizatidina ChemIDplus
nizatidine WHO MedNet
nizatidine KEGG DRUG
nizatidinum ChemIDplus
Synonym Source
N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamine ChemIDplus
Brand Names Sources
Acinon KEGG DRUG
Axid KEGG DRUG
Manual Xrefs Databases
1955 DrugCentral
C07270 KEGG COMPOUND
D00440 KEGG DRUG
DB00585 DrugBank
HMDB0014723 HMDB
LSM-3031 LINCS
Nizatidine Wikipedia
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Registry Numbers Types Sources
4846056 Reaxys Registry Number Reaxys
76963-41-2 CAS Registry Number KEGG COMPOUND
76963-41-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
12520631 PubMed citation Europe PMC
20435237 PubMed citation Europe PMC
20881754 PubMed citation Europe PMC
21858296 PubMed citation Europe PMC
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Last Modified
22 February 2017