CHEBI:7577 - nisoldipine

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ChEBI Name nisoldipine
Definition A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent
A drug used to cause dilation of the blood vessels.
platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
cardiovascular drug
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
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ChEBI Ontology
Outgoing nisoldipine (CHEBI:7577) has part (R)-nisoldipine (CHEBI:76918)
nisoldipine (CHEBI:7577) has part (S)-nisoldipine (CHEBI:76919)
nisoldipine (CHEBI:7577) has role antihypertensive agent (CHEBI:35674)
nisoldipine (CHEBI:7577) has role calcium channel blocker (CHEBI:38215)
nisoldipine (CHEBI:7577) has role cardiovascular drug (CHEBI:35554)
nisoldipine (CHEBI:7577) has role platelet aggregation inhibitor (CHEBI:50427)
nisoldipine (CHEBI:7577) has role vasodilator agent (CHEBI:35620)
nisoldipine (CHEBI:7577) is a racemate (CHEBI:60911)
rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INNs Sources
nisoldipine WHO MedNet
nisoldipine KEGG DRUG
nisoldipino ChemIDplus
nisoldipinum ChemIDplus
Synonyms Sources
(±)-isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate ChemIDplus
1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester NIST Chemistry WebBook
Brand Names Sources
Baymycard DrugBank
Syscor DrugBank
Zadipina DrugBank
Manual Xrefs Databases
DB00401 DrugBank
DE2549568 Patent
HMDB0014545 HMDB
Nisoldipine Wikipedia
US4154839 Patent
View more database links
Registry Numbers Types Sources
454188 Reaxys Registry Number Reaxys
63675-72-9 CAS Registry Number NIST Chemistry WebBook
63675-72-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
23841582 PubMed citation Europe PMC
2667729 PubMed citation Europe PMC
3154674 PubMed citation Europe PMC
8150600 PubMed citation Europe PMC
8429113 PubMed citation Europe PMC
8592476 PubMed citation Europe PMC
Last Modified
21 April 2017