CHEBI:7553 - niclosamide

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name niclosamide
Definition A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:92630
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C13H8Cl2N2O4
Net Charge 0
Average Mass 327.120
Monoisotopic Mass 325.98611
InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
SMILES OC1=CC=C(Cl)C=C1C(=O)NC1=C(Cl)C=C(C=C1)[N+]([O-])=O
Roles Classification
Biological Role(s): anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
STAT3 inhibitor
An inhibitor of signal transducer and activator of transcription 3 (STAT3)
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
(via salicylamide )
Application(s): antiparasitic agent
A substance used to treat or prevent parasitic infections.
anthelminthic drug
Substance intended to kill parasitic worms (helminths).
A substance which is poisonous to fish and is primarily used to eliminate dominant species of fish in water.
A substance used to destroy pests of the phylum Mollusca.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
(via salicylamide )
antirheumatic drug
A drug used to treat rheumatoid arthritis.
(via salicylamide )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing niclosamide (CHEBI:7553) has functional parent 5-chlorosalicylic acid (CHEBI:420128)
niclosamide (CHEBI:7553) has role anthelminthic drug (CHEBI:35443)
niclosamide (CHEBI:7553) has role anticoronaviral agent (CHEBI:149553)
niclosamide (CHEBI:7553) has role antiparasitic agent (CHEBI:35442)
niclosamide (CHEBI:7553) has role apoptosis inducer (CHEBI:68495)
niclosamide (CHEBI:7553) has role molluscicide (CHEBI:33904)
niclosamide (CHEBI:7553) has role piscicide (CHEBI:167183)
niclosamide (CHEBI:7553) has role STAT3 inhibitor (CHEBI:87183)
niclosamide (CHEBI:7553) is a C-nitro compound (CHEBI:35716)
niclosamide (CHEBI:7553) is a benzamides (CHEBI:22702)
niclosamide (CHEBI:7553) is a monochlorobenzenes (CHEBI:83403)
niclosamide (CHEBI:7553) is a salicylanilides (CHEBI:53468)
niclosamide (CHEBI:7553) is a secondary carboxamide (CHEBI:140325)
INNs Sources
niclosamida WHO MedNet
niclosamide WHO MedNet
niclosamide WHO MedNet
niclosamidum WHO MedNet
Synonyms Sources
2',5-dichloro-2-hydroxy-4'-nitrobenzanilide Alan Wood's Pesticides
2',5-dichloro-4'-nitrosalicylanilide Alan Wood's Pesticides
2-chloro-4-nitrophenylamide-6-chlorosalicylic acid ChemIDplus
2-hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide ChemIDplus
5-chloro-2'-chloro-4'-nitrosalicylanilide ChemIDplus
5-chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide ChemIDplus
B 2353 ChemIDplus
BAY 2353 ChemIDplus
Bayer 2353 ChemIDplus
Bayer 73 ChemIDplus
clonitralide DrugCentral
HL 2447 ChemIDplus
N-(2'-chloro-4'-nitrophenyl)-5-chlorosalicylamide ChEBI
N-(2-chloro-4-nitrophenyl)-5-chlorosalicylamide ChemIDplus
WR 46234 ChemIDplus
Brand Names Sources
Atenase ChemIDplus
Bayluscide ChemIDplus
Cestocid ChemIDplus
Devermin ChemIDplus
Devermine ChemIDplus
Fedal-Telmin ChemIDplus
Fenasal ChemIDplus
Helmiantin ChemIDplus
Iomesan ChemIDplus
Lintex ChemIDplus
Mansonil ChemIDplus
Mato ChemIDplus
Nasemo ChemIDplus
Niclocide KEGG DRUG
Phenasal ChemIDplus
Radeverm ChemIDplus
Sagimid ChemIDplus
Sulqui ChemIDplus
Tredemine ChemIDplus
Utosamide ChEBI
Vermitid ChemIDplus
Vermitin ChemIDplus
Yomesan ChemIDplus
Zestocarp ChemIDplus
Manual Xrefs Databases
1912 DrugCentral
1929 PPDB
1929 VSDB
4322 ChemSpider
DB06803 DrugBank
HMDB0015679 HMDB
niclosamide Alan Wood's Pesticides
Niclosamide Wikipedia
View more database links
Registry Numbers Types Sources
2820605 Reaxys Registry Number Reaxys
50-65-7 CAS Registry Number ChemIDplus
50-65-7 CAS Registry Number NIST Chemistry WebBook
Citations Waiting for Citations Types Sources
24900231 PubMed citation Europe PMC
33325188 PubMed citation Europe PMC
33772737 PubMed citation Europe PMC
33855343 PubMed citation Europe PMC
33860549 PubMed citation Europe PMC
33870260 PubMed citation Europe PMC
34038481 PubMed citation Europe PMC
34209118 PubMed citation Europe PMC
34332199 PubMed citation Europe PMC
34386088 PubMed citation Europe PMC
34429248 PubMed citation Europe PMC
34482191 PubMed citation Europe PMC
34483712 PubMed citation Europe PMC
34512959 PubMed citation Europe PMC
34517104 PubMed citation Europe PMC
34572856 PubMed citation Europe PMC
34638761 PubMed citation Europe PMC
PMC8308039 PubMed Central citation Europe PMC
PMC8508655 PubMed Central citation Europe PMC
Last Modified
14 October 2021