CHEBI:75451 - gastrin-14

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ChEBI Name gastrin-14
ChEBI ID CHEBI:75451
Definition One of the primary forms of gastrin that is a 14-membered peptide consisting of Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe residues joined in sequence.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C85H109N17O27S
Net Charge 0
Average Mass 1832.93800
Monoisotopic Mass 1831.73995
InChI InChI=1S/C85H109N17O27S/c1-43(2)34-62(101-75(119)52(86)37-47-40-88-53-16-10-8-14-50(47)53)83(127)97-59(26-31-71(113)114)81(125)96-58(25-30-70(111)112)80(124)95-57(24-29-69(109)110)79(123)94-56(23-28-68(107)108)78(122)93-55(22-27-67(105)106)77(121)91-44(3)74(118)100-63(36-46-18-20-49(103)21-19-46)76(120)90-42-66(104)92-64(38-48-41-89-54-17-11-9-15-51(48)54)84(128)98-60(32-33-130-4)82(126)102-65(39-72(115)116)85(129)99-61(73(87)117)35-45-12-6-5-7-13-45/h5-21,40-41,43-44,52,55-65,88-89,103H,22-39,42,86H2,1-4H3,(H2,87,117)(H,90,120)(H,91,121)(H,92,104)(H,93,122)(H,94,123)(H,95,124)(H,96,125)(H,97,127)(H,98,128)(H,99,129)(H,100,118)(H,101,119)(H,102,126)(H,105,106)(H,107,108)(H,109,110)(H,111,112)(H,113,114)(H,115,116)/t44-,52-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-/m0/s1
InChIKey SSBRJDBGIVUNDK-QOGDCIHTSA-N
SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): cholecystokinin antagonist
A hormone antagonist that inhibits the action of the peptide hormone cholecystokinin.
(via gastrin )
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via gastrin )
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via peptide hormone )
Application(s): cholecystokinin antagonist
A hormone antagonist that inhibits the action of the peptide hormone cholecystokinin.
(via gastrin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing gastrin-14 (CHEBI:75451) is a gastrin (CHEBI:75436)
gastrin-14 (CHEBI:75451) is a peptidyl amide (CHEBI:15722)
IUPAC Name
L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalanine
Synonyms Sources
22-34-Gastrin ChemIDplus
Gastrin (21-34) ChemIDplus
Gastrin tetradecapeptide ChemIDplus
Minigastrin KEGG COMPOUND
Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe ChEBI
Manual Xrefs Databases
C18186 KEGG COMPOUND
EP2187936 Patent
View more database links
Registry Number Type Source
60748-07-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
21139504 PubMed citation Europe PMC
21993546 PubMed citation Europe PMC
23441851 PubMed citation Europe PMC
23591397 PubMed citation Europe PMC
Last Modified
10 August 2017