CHEBI:75404 - tyrphostin AG 1478

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ChEBI Name tyrphostin AG 1478
ChEBI ID CHEBI:75404
Definition A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H14ClN3O2
Net Charge 0
Average Mass 315.755
Monoisotopic Mass 315.077
InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChIKey GFNNBHLJANVSQV-UHFFFAOYSA-N
SMILES C12=CC(=C(C=C1C(=NC=N2)NC=3C=CC=C(C3)Cl)OC)OC
Roles Classification
Biological Role(s): epidermal growth factor receptor antagonist
An antagonist at the epidermal growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing tyrphostin AG 1478 (CHEBI:75404) has role antineoplastic agent (CHEBI:35610)
tyrphostin AG 1478 (CHEBI:75404) has role epidermal growth factor receptor antagonist (CHEBI:74440)
tyrphostin AG 1478 (CHEBI:75404) is a aromatic ether (CHEBI:35618)
tyrphostin AG 1478 (CHEBI:75404) is a monochlorobenzenes (CHEBI:83403)
tyrphostin AG 1478 (CHEBI:75404) is a quinazolines (CHEBI:38530)
IUPAC Name
N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine
Synonyms Sources
AG 1478 ChemIDplus
AG-1478 ChemIDplus
tyrphostin AG-1478 ChEBI
Manual Xrefs Databases
0TO PDBeChem
LSM-1224 LINCS
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Registry Numbers Types Sources
170449-18-0 CAS Registry Number ChemIDplus
7437034 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
20008468 PubMed citation Europe PMC
22646904 PubMed citation Europe PMC
8752145 PubMed citation Europe PMC
Last Modified
08 March 2016