CHEBI:75292 - phenanthridone

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ChEBI Name phenanthridone
ChEBI ID CHEBI:75292
Definition A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C13H9NO
Net Charge 0
Average Mass 195.21670
Monoisotopic Mass 195.068
InChI InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChIKey RZFVLEJOHSLEFR-UHFFFAOYSA-N
SMILES O=c1[nH]c2ccccc2c2ccccc12
Roles Classification
Biological Role(s): mutagen
An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD+ ADP-ribosyltransferase (EC 2.4.2.30).
Application(s): immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
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ChEBI Ontology
Outgoing phenanthridone (CHEBI:75292) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913)
phenanthridone (CHEBI:75292) has role immunosuppressive agent (CHEBI:35705)
phenanthridone (CHEBI:75292) has role mutagen (CHEBI:25435)
phenanthridone (CHEBI:75292) is a lactam (CHEBI:24995)
phenanthridone (CHEBI:75292) is a phenanthridines (CHEBI:51245)
IUPAC Name
phenanthridin-6(5H)-one
Synonyms Sources
6-Phenanthridinol ChemIDplus
6-Phenanthridinone ChemIDplus
6-Phenanthridone ChemIDplus
Manual Xrefs Databases
LSM-2229 LINCS
US2478805 Patent
View more database links
Registry Numbers Types Sources
1015-89-0 CAS Registry Number NIST Chemistry WebBook
1015-89-0 CAS Registry Number ChemIDplus
140641 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
11202649 PubMed citation Europe PMC
19447472 PubMed citation Europe PMC
2858381 PubMed citation Europe PMC
3464317 PubMed citation Europe PMC
6302951 PubMed citation Europe PMC
7672878 PubMed citation Europe PMC
Last Modified
24 February 2016