CHEBI:75179 - trifluridine

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ChEBI Name trifluridine
ChEBI ID CHEBI:75179
Definition A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:9713
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Formula C10H11F3N2O5
Net Charge 0
Average Mass 296.19990
Monoisotopic Mass 296.062
InChI InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChIKey VSQQQLOSPVPRAZ-RRKCRQDMSA-N
SMILES OC[C@H]1O[C@H](C[C@@H]1O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Roles Classification
Biological Role(s): antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
antimetabolite
A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
EC 2.1.1.45 (thymidylate synthase) inhibitor
An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of thymidylate synthase (EC 2.1.1.45).
Application(s): antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing trifluridine (CHEBI:75179) has role antimetabolite (CHEBI:35221)
trifluridine (CHEBI:75179) has role antineoplastic agent (CHEBI:35610)
trifluridine (CHEBI:75179) has role antiviral drug (CHEBI:36044)
trifluridine (CHEBI:75179) has role EC 2.1.1.45 (thymidylate synthase) inhibitor (CHEBI:63720)
trifluridine (CHEBI:75179) is a nucleoside analogue (CHEBI:60783)
trifluridine (CHEBI:75179) is a organofluorine compound (CHEBI:37143)
trifluridine (CHEBI:75179) is a pyrimidine 2'-deoxyribonucleoside (CHEBI:19255)
Incoming Lonsurf (CHEBI:90876) has part trifluridine (CHEBI:75179)
IUPAC Name
2'-deoxy-5-(trifluoromethyl)uridine
INNs Sources
trifluridina DrugBank
trifluridine WHO MedNet
trifluridine DrugBank
trifluridinum ChemIDplus
Synonyms Sources
5-(Trifluoromethyl)deoxyuridine ChemIDplus
5-Trifluoromethyl-2-deoxyuridine ChemIDplus
Trifluoromethyldeoxyuridine DrugBank
Trifluorothymidine DrugBank
trifluorothymine deoxyriboside DrugBank
Brand Name Source
Viroptic KEGG DRUG
Manual Xrefs Databases
2743 DrugCentral
D00391 KEGG DRUG
DB00432 DrugBank
HMDB0014576 HMDB
LSM-5217 LINCS
Trifluridine Wikipedia
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Registry Numbers Types Sources
568095 Reaxys Registry Number Reaxys
70-00-8 CAS Registry Number KEGG DRUG
70-00-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017