CHEBI:72299 - lomitapide mesylate

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ChEBI Name lomitapide mesylate
Definition A methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C40H41F6N3O5S
Net Charge 0
Average Mass 789.82600
Monoisotopic Mass 789.26711
InChI InChI=1S/C39H37F6N3O2.CH4O3S/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45;1-5(2,3)4/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49);1H3,(H,2,3,4)
SMILES CS(O)(=O)=O.FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12
Roles Classification
Biological Role(s): MTP inhibitor
An inhibitor that interferes with the action of MTP.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing lomitapide mesylate (CHEBI:72299) has part lomitapide(1+) (CHEBI:72302)
lomitapide mesylate (CHEBI:72299) has role anticholesteremic drug (CHEBI:35821)
lomitapide mesylate (CHEBI:72299) has role MTP inhibitor (CHEBI:72298)
lomitapide mesylate (CHEBI:72299) is a methanesulfonate salt (CHEBI:38037)
1-(4-{9-[(2,2,2-trifluoroethyl)carbamoyl]-9H-fluoren-9-yl}butyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidinium methanesulfonate
N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide methanesulfonate
Synonyms Sources
AEGR-733 ChemIDplus
BMS-201038 ChemIDplus
BMS-201038-04 ChemIDplus
Brand Names Sources
Juxtapid ChemIDplus
lomitapide methanesulfonate ChEBI
lomitapide monomesylate ChEBI
Manual Xrefs Databases
WO2005087234 Patent
WO2007047722 Patent
View more database links
Registry Numbers Types Sources
14506420 Reaxys Registry Number Reaxys
202914-84-9 CAS Registry Number ChemIDplus
202914-84-9 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
12445582 PubMed citation Europe PMC
17215532 PubMed citation Europe PMC
21401695 PubMed citation Europe PMC
Last Modified
07 March 2013