CHEBI:71258 - pitavastatin calcium

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name pitavastatin calcium
Definition The calcium salt of pitavastatin. Used for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C50H46CaF2N2O8
Net Charge 0
Average Mass 880.98400
Monoisotopic Mass 880.28481
InChI InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1
SMILES [Ca++].O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Role(s): EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
(via statin )
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
(via statin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing pitavastatin calcium (CHEBI:71258) has part pitavastatin(1−) (CHEBI:71260)
pitavastatin calcium (CHEBI:71258) has role antioxidant (CHEBI:22586)
pitavastatin calcium (CHEBI:71258) is a calcium salt (CHEBI:35156)
pitavastatin calcium (CHEBI:71258) is a statin (synthetic) (CHEBI:87635)
calcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate}
Synonyms Sources
Bis((3R,5S,6E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate) monocalcium salt ChemIDplus
Pitavastatin hemicalcium ChemIDplus
Manual Xrefs Databases
EP2383260 Patent
KR20110092804 Patent
KR20110097058 Patent
Pitavastatin Wikipedia
US2009182008 Patent
US2011082298 Patent
US2011319624 Patent
US2012016129 Patent
US2012101126 Patent
WO2005063711 Patent
WO2007125547 Patent
WO2007132482 Patent
WO2011105649 Patent
WO2012002741 Patent
WO2012025939 Patent
View more database links
Registry Numbers Types Sources
147526-32-7 CAS Registry Number KEGG DRUG
147526-32-7 CAS Registry Number ChemIDplus
7965530 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
20621877 PubMed citation Europe PMC
20664824 PubMed citation Europe PMC
20852754 PubMed citation Europe PMC
21069103 PubMed citation Europe PMC
21225019 PubMed citation Europe PMC
21381428 PubMed citation Europe PMC
21651447 PubMed citation Europe PMC
21816477 PubMed citation Europe PMC
Last Modified
24 August 2015