CHEBI:71219 - pazopanib

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ChEBI Name pazopanib
ChEBI ID CHEBI:71219
Definition A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H23N7O2S
Net Charge 0
Average Mass 437.51800
Monoisotopic Mass 437.16339
InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChIKey CUIHSIWYWATEQL-UHFFFAOYSA-N
SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis modulating agent
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
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ChEBI Ontology
Outgoing pazopanib (CHEBI:71219) has role angiogenesis modulating agent (CHEBI:50926)
pazopanib (CHEBI:71219) has role antineoplastic agent (CHEBI:35610)
pazopanib (CHEBI:71219) has role tyrosine kinase inhibitor (CHEBI:38637)
pazopanib (CHEBI:71219) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
pazopanib (CHEBI:71219) is a aminopyrimidine (CHEBI:38338)
pazopanib (CHEBI:71219) is a indazoles (CHEBI:38769)
pazopanib (CHEBI:71219) is a sulfonamide (CHEBI:35358)
pazopanib (CHEBI:71219) is conjugate base of pazopanib(1+) (CHEBI:71218)
Incoming pazopanib(1+) (CHEBI:71218) is conjugate acid of pazopanib (CHEBI:71219)
IUPAC Name
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
INNs Sources
pazopanib WHO MedNet
pazopanib WHO MedNet
pazopanib WHO MedNet
pazopanibum WHO MedNet
Synonyms Sources
GW 78603 ChemIDplus
GW786034 ChemIDplus
Manual Xrefs Databases
4118 DrugCentral
LSM-1114 LINCS
Pazopanib Wikipedia
US2008293691 Patent
WO2006020564 Patent
WO2007064753 Patent
WO2007143483 Patent
WO2011058179 Patent
WO2011069053 Patent
WO2011150044 Patent
WO2012106302 Patent
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Registry Numbers Types Sources
11646488 Reaxys Registry Number Reaxys
444731-52-6 CAS Registry Number ChemIDplus
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Last Modified
22 February 2017