CHEBI:71217 - pazopanib hydrochloride

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ChEBI Name pazopanib hydrochloride
ChEBI ID CHEBI:71217
Definition A hydrochloride salt prepared from equimolar amounts of pazopanib and hydrochloric acid. Used for treatment of kidney cancer.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H24ClN7O2S
Net Charge 0
Average Mass 473.97900
Monoisotopic Mass 473.140
InChI InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
InChIKey MQHIQUBXFFAOMK-UHFFFAOYSA-N
SMILES Cl.CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
Roles Classification
Biological Role(s): vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
Application(s): angiogenesis modulating agent
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing pazopanib hydrochloride (CHEBI:71217) has part pazopanib(1+) (CHEBI:71218)
pazopanib hydrochloride (CHEBI:71217) has role angiogenesis modulating agent (CHEBI:50926)
pazopanib hydrochloride (CHEBI:71217) has role antineoplastic agent (CHEBI:35610)
pazopanib hydrochloride (CHEBI:71217) has role tyrosine kinase inhibitor (CHEBI:38637)
pazopanib hydrochloride (CHEBI:71217) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
pazopanib hydrochloride (CHEBI:71217) is a hydrochloride (CHEBI:36807)
IUPAC Name
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide hydrochloride
Synonyms Sources
5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide monohydrochloride ChemIDplus
GW786034B ChemIDplus
pazopanib HCl ChEBI
pazopanib monohydrochloride ChEBI
Brand Name Source
Votrient KEGG DRUG
Manual Xrefs Databases
D05380 KEGG DRUG
Pazopanib_hydrochloride Wikipedia
US2008293691 Patent
WO2005105094 Patent
WO2006020564 Patent
WO2007064753 Patent
WO2007143483 Patent
WO2009062658 Patent
WO2011069053 Patent
WO2011150044 Patent
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Registry Numbers Types Sources
11572612 Reaxys Registry Number Reaxys
635702-64-6 CAS Registry Number ChemIDplus
635702-64-6 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
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Last Modified
22 November 2012