CHEBI:71028 - carglumic acid

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ChEBI Name carglumic acid
Definition A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C6H10N2O5
Net Charge 0
Average Mass 190.15400
Monoisotopic Mass 190.05897
InChI InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): carbamylphosphate synthetase I activator
Any compound that binds and activates the enzyme carbamylphosphate synthetase I.
Application(s): orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
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ChEBI Ontology
Outgoing carglumic acid (CHEBI:71028) has role carbamylphosphate synthetase I activator (CHEBI:71033)
carglumic acid (CHEBI:71028) has role orphan drug (CHEBI:71031)
carglumic acid (CHEBI:71028) is a N-acyl-L-glutamic acid (CHEBI:21650)
carglumic acid (CHEBI:71028) is a ureas (CHEBI:47857)
N-carbamoyl-L-glutamic acid
INNs Sources
acide carglumique WHO MedNet
ácido carglúmico WHO MedNet
acidum carglumicum WHO MedNet
carglumic acid KEGG DRUG
Synonyms Sources
(2S)-2-(carbamoylamino)pentanedioic acid HMDB
Carbamino-L-glutamic acid ChemIDplus
Carbamylglutamic acid ChemIDplus
L-N-Carbamoylglutamic acid ChemIDplus
Ureidoglutaric acid ChemIDplus
Brand Name Source
Carbaglu KEGG DRUG
Manual Xrefs Databases
3068 DrugCentral
Carglumic_acid Wikipedia
DB06775 DrugBank
HMDB0015673 HMDB
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Registry Numbers Types Sources
1188-38-1 CAS Registry Number KEGG DRUG
1188-38-1 CAS Registry Number ChemIDplus
1727929 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
15055204 PubMed citation Europe PMC
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Last Modified
22 February 2017