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ChEBI
> Main
CHEBI:71019 - omacetaxine mepesuccinate
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ChEBI Name
omacetaxine mepesuccinate
ChEBI ID
CHEBI:71019
Definition
A cephalotaxine-derived alkaloid ester obtained from
Cephalotaxus harringtonia
; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Stars
This entity has been manually annotated by the ChEBI Team.
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Wikipedia
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Read full article at Wikipedia
Formula
C29H39NO9
Net Charge
0
Average Mass
545.62130
Monoisotopic Mass
545.26248
InChI
InChI=1S/C29H39NO9/c1-
27(2,33)
8-
5-
10-
29(34,16-
23(31)
36-
4)
26(32)
39-
25-
22(35-
3)
15-
28-
9-
6-
11-
30(28)
12-
7-
18-
13-
20-
21(38-
17-
37-
20)
14-
19(18)
24(25)
28/h13-
15,24-
25,33-
34H,5-
12,16-
17H2,1-
4H3/t24-
,25-
,28+,29-
/m1/s1
InChIKey
HYFHYPWGAURHIV-JFIAXGOJSA-N
SMILES
[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21
Roles Classification
Biological Role
(s):
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
protein synthesis inhibitor
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via
alkaloid
)
Application
(s):
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
omacetaxine mepesuccinate (
CHEBI:71019
)
has functional parent
cephalotaxine (
CHEBI:3540
)
omacetaxine mepesuccinate (
CHEBI:71019
)
has role
anticoronaviral agent (
CHEBI:149553
)
omacetaxine mepesuccinate (
CHEBI:71019
)
has role
antineoplastic agent (
CHEBI:35610
)
omacetaxine mepesuccinate (
CHEBI:71019
)
has role
apoptosis inducer (
CHEBI:68495
)
omacetaxine mepesuccinate (
CHEBI:71019
)
has role
protein synthesis inhibitor (
CHEBI:48001
)
omacetaxine mepesuccinate (
CHEBI:71019
)
is a
alkaloid ester (
CHEBI:38481
)
omacetaxine mepesuccinate (
CHEBI:71019
)
is a
enol ether (
CHEBI:47985
)
omacetaxine mepesuccinate (
CHEBI:71019
)
is a
organic heteropentacyclic compound (
CHEBI:38164
)
omacetaxine mepesuccinate (
CHEBI:71019
)
is a
tertiary alcohol (
CHEBI:26878
)
INNs
Sources
mépésuccinate d'omacétaxine
WHO MedNet
mepesuccinato de omacetaxina
WHO MedNet
omacetaxine mepesuccinate
WHO MedNet
omacetaxini mepesuccinas
WHO MedNet
Synonyms
Sources
(−)-homoharringtonine
ChEBI
(2'
R
,3
S
,4
S
,5
R
)-(−)-homoharringtonine
ChEBI
CGX-635
ChemIDplus
Homoharringtonine
KEGG DRUG
Brand Name
Source
Synribo
ChemIDplus
Manual Xrefs
Databases
4677
DrugCentral
D08956
KEGG DRUG
HMT
PDBeChem
LSM-3716
LINCS
Omacetaxine_mepesuccinate
Wikipedia
US2010240887
Patent
WO2007089878
Patent
View more database links
Registry Numbers
Types
Sources
26833-87-4
CAS Registry Number
ChemIDplus
26833-87-4
CAS Registry Number
KEGG DRUG
5687925
Reaxys Registry Number
Reaxys
5687925
Beilstein Registry Number
ChemIDplus
Citations
Types
Sources
20971952
PubMed citation
Europe PMC
21152934
PubMed citation
Europe PMC
21258877
PubMed citation
Europe PMC
21294709
PubMed citation
Europe PMC
21415308
PubMed citation
Europe PMC
21418889
PubMed citation
Europe PMC
21468038
PubMed citation
Europe PMC
21509439
PubMed citation
Europe PMC
21845438
PubMed citation
Europe PMC
21916787
PubMed citation
Europe PMC
22040954
PubMed citation
Europe PMC
22054289
PubMed citation
Europe PMC
22075327
PubMed citation
Europe PMC
22289991
PubMed citation
Europe PMC
22391162
PubMed citation
Europe PMC
22580751
PubMed citation
Europe PMC
22714632
PubMed citation
Europe PMC
22896000
PubMed citation
Europe PMC
22898909
PubMed citation
Europe PMC
22917222
PubMed citation
Europe PMC
22967374
PubMed citation
Europe PMC
23053254
PubMed citation
Europe PMC
23059828
PubMed citation
Europe PMC
23086639
PubMed citation
Europe PMC
23109844
PubMed citation
Europe PMC
23456623
PubMed citation
Europe PMC
Last Modified
23 April 2020