CHEBI:71013 - perampanel

Main ChEBI Ontology Automatic Xrefs
ChEBI Name perampanel
ChEBI ID CHEBI:71013
Definition A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C23H15N3O
Net Charge 0
Average Mass 349.38470
InChI InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
InChIKey PRMWGUBFXWROHD-UHFFFAOYSA-N
SMILES O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N
Roles Classification
Biological Role(s): AMPA receptor antagonist
An antagonist at the AMPA receptor.
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
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ChEBI Ontology
Outgoing perampanel (CHEBI:71013) has functional parent benzonitrile (CHEBI:27991)
perampanel (CHEBI:71013) has role AMPA receptor antagonist (CHEBI:71014)
perampanel (CHEBI:71013) has role anticonvulsant (CHEBI:35623)
perampanel (CHEBI:71013) is a bipyridines (CHEBI:50511)
perampanel (CHEBI:71013) is a nitrile (CHEBI:18379)
perampanel (CHEBI:71013) is a pyridone (CHEBI:38183)
Incoming perampanel hydrate (CHEBI:71015) has part perampanel (CHEBI:71013)
IUPAC Name
2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
INNs Sources
perampanel WHO MedNet
perampanel WHO MedNet
pérampanel WHO MedNet
perampanelum WHO MedNet
Synonyms Sources
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one ChemIDplus
E 2007 ChemIDplus
E2007 ChemIDplus
ER-155055-90 ChemIDplus
Brand Name Source
Fycompa KEGG DRUG
Database Links Databases
D08964 KEGG DRUG
EP1875912 Patent
Perampanel Wikipedia
US2008108603 Patent
US2009088574 Patent
WO2006107859 Patent
WO2008111590 Patent
View more database links
Registry Numbers Types Sources
11343244 Reaxys Registry Number Reaxys
380917-97-5 CAS Registry Number ChemIDplus
380917-97-5 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
21635236 PubMed citation CiteXplore
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Last Modified
16 January 2013