CHEBI:71013 - perampanel

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ChEBI Name perampanel
Definition A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C23H15N3O
Net Charge 0
Average Mass 349.38470
Monoisotopic Mass 349.12151
InChI InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
SMILES O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N
Roles Classification
Biological Role(s): AMPA receptor antagonist
An antagonist at the AMPA receptor.
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
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ChEBI Ontology
Outgoing perampanel (CHEBI:71013) has functional parent benzonitrile (CHEBI:27991)
perampanel (CHEBI:71013) has role AMPA receptor antagonist (CHEBI:71014)
perampanel (CHEBI:71013) has role anticonvulsant (CHEBI:35623)
perampanel (CHEBI:71013) is a bipyridines (CHEBI:50511)
perampanel (CHEBI:71013) is a nitrile (CHEBI:18379)
perampanel (CHEBI:71013) is a pyridone (CHEBI:38183)
Incoming perampanel hydrate (CHEBI:71015) has part perampanel (CHEBI:71013)
INNs Sources
perampanel WHO MedNet
perampanel WHO MedNet
pérampanel WHO MedNet
perampanelum WHO MedNet
Synonyms Sources
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one ChemIDplus
E 2007 ChemIDplus
E2007 ChemIDplus
ER-155055-90 ChemIDplus
Brand Name Source
Manual Xrefs Databases
4684 DrugCentral
EP1875912 Patent
Perampanel Wikipedia
US2008108603 Patent
US2009088574 Patent
WO2006107859 Patent
WO2008111590 Patent
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Registry Numbers Types Sources
11343244 Reaxys Registry Number Reaxys
380917-97-5 CAS Registry Number KEGG DRUG
380917-97-5 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017