methdilazine (CHEBI:6823)

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ChEBI Name	methdilazine

ChEBI ID	CHEBI:6823

Definition	A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C18H20N2S

Net Charge

Average Mass

296.432

InChI

InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3

InChIKey

HTMIBDQKFHUPSX-UHFFFAOYSA-N

SMILES

C1=CC=C2C(=C1)SC=3C(N2CC4CN(CC4)C)=CC=CC3

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

Application(s):	antipruritic drug A drug, usually applied topically, that relieves pruritus (itching). histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

ChEBI Ontology
Outgoing	methdilazine (CHEBI:6823) has role antipruritic drug (CHEBI:59683) methdilazine (CHEBI:6823) has role cholinergic antagonist (CHEBI:48873) methdilazine (CHEBI:6823) has role histamine antagonist (CHEBI:37956) methdilazine (CHEBI:6823) is a N-alkylpyrrolidine (CHEBI:46775) methdilazine (CHEBI:6823) is a phenothiazines (CHEBI:38093)

Incoming	methdilazine hydrochloride (CHEBI:140855) has part methdilazine (CHEBI:6823)

IUPAC Name

10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine

Synonyms	Sources
10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine	ChEBI
Methdilazine	KEGG COMPOUND
MJ 5022	NIST Chemistry WebBook

Last Modified

19 December 2019