CHEBI:681850 - conivaptan

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ChEBI Name conivaptan
ChEBI ID CHEBI:681850
Definition The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C32H26N4O2
Net Charge 0
Average Mass 498.57440
Monoisotopic Mass 498.206
InChI InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
InChIKey IKENVDNFQMCRTR-UHFFFAOYSA-N
SMILES Cc1nc2CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c3ccccc3-c2[nH]1
Roles Classification
Biological Role(s): vasopressin receptor antagonist
Any drug which blocks vasopressin receptors.
Application(s): vasopressin receptor antagonist
Any drug which blocks vasopressin receptors.
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ChEBI Ontology
Outgoing conivaptan (CHEBI:681850) has role vasopressin receptor antagonist (CHEBI:59680)
conivaptan (CHEBI:681850) is a benzazepine (CHEBI:35676)
Incoming conivaptan hydrochloride (CHEBI:31430) has part conivaptan (CHEBI:681850)
IUPAC Name
N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
INN Source
conivaptan ChemIDplus
Synonyms Sources
4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide ChemIDplus
Conivaptan ChEMBL
Manual Xrefs Databases
732 DrugCentral
Conivaptan Wikipedia
D07748 KEGG DRUG
DB00872 DrugBank
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Registry Numbers Types Sources
210101-16-9 CAS Registry Number KEGG DRUG
210101-16-9 CAS Registry Number ChemIDplus
8658375 Beilstein Registry Number Beilstein
Citation Waiting for Citations Type Source
20070106 PubMed citation ChEMBL
Last Modified
22 February 2017