CHEBI:64598 - 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one

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ChEBI Name 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
Definition A differentiation-inducing factor that is hexaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls cell fate during development of Dictyostelium cells.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Rebecca Foulger
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Formula C13H16Cl2O4
Net Charge 0
Average Mass 307.170
Monoisotopic Mass 306.04256
InChI InChI=1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3
Metabolite of Species Details
Dictyostelium (NCBI:txid5782) See: PubMed
Roles Classification
Biological Role(s): signalling molecule
A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell.
eukaryotic metabolite
Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
(via differentiation-inducing factor )
A small molecule which increases (activator) or decreases (inhibitor) the activity of an (allosteric) enzyme by binding to the enzyme at the regulatory site (which is different from the substrate-binding catalytic site).
(via differentiation-inducing factor )
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ChEBI Ontology
Outgoing 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) has functional parent (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one (CHEBI:90396)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) has role eukaryotic metabolite (CHEBI:75763)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) has role signalling molecule (CHEBI:62488)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a dichlorobenzene (CHEBI:23697)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a differentiation-inducing factor (CHEBI:64672)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a monomethoxybenzene (CHEBI:25235)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a resorcinols (CHEBI:33572)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is conjugate acid of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one(1−) (CHEBI:90397)
Incoming 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one(1−) (CHEBI:90397) is conjugate base of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598)
Synonyms Sources
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone ChemIDplus
Dif-1 (dictyostelium) ChemIDplus
Differentiation-inducing factor 1 SUBMITTER
differentiation-inducing factor-1 SUBMITTER
Morphogen differentiation inducing factor (dictyostelium) ChemIDplus
Manual Xref Database
Differentiation-inducing_factor Wikipedia
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Registry Numbers Types Sources
111050-72-7 CAS Registry Number ChemIDplus
9789620 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
12555068 PubMed citation Europe PMC
1521542 PubMed citation Europe PMC
15333995 PubMed citation Europe PMC
15470253 PubMed citation Europe PMC
1731750 PubMed citation Europe PMC
18305004 PubMed citation Europe PMC
19414353 PubMed citation Europe PMC
20231486 PubMed citation Europe PMC
20843378 PubMed citation Europe PMC
7777565 PubMed citation Europe PMC
8421680 PubMed citation Europe PMC
9446571 PubMed citation Europe PMC
Last Modified
24 January 2017