CHEBI:64022 - nebivolol

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ChEBI Name nebivolol
ChEBI ID CHEBI:64022
Definition A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
vasodilator agent
A drug used to cause dilation of the blood vessels.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
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ChEBI Ontology
Outgoing nebivolol (CHEBI:64022) has part (R,S,S,S)-nebivolol (CHEBI:64020)
nebivolol (CHEBI:64022) has part (S,R,R,R)-nebivolol (CHEBI:64021)
nebivolol (CHEBI:64022) has role β-adrenergic antagonist (CHEBI:35530)
nebivolol (CHEBI:64022) has role antihypertensive agent (CHEBI:35674)
nebivolol (CHEBI:64022) has role vasodilator agent (CHEBI:35620)
nebivolol (CHEBI:64022) is a racemate (CHEBI:60911)
INNs Sources
nebivolol ChemIDplus
nebivololum ChEBI
Synonyms Sources
(1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol ChEBI
(1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol} ChEBI
dl-nebivolol ChemIDplus
Manual Xrefs Databases
D05127 KEGG DRUG
DB04861 DrugBank
Nebivolol Wikipedia
US4654362 Patent
View more database links
Registry Numbers Types Sources
118457-14-0 CAS Registry Number ChemIDplus
4789059 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
17661735 PubMed citation Europe PMC
18078016 PubMed citation Europe PMC
18083889 PubMed citation Europe PMC
18221115 PubMed citation Europe PMC
18786089 PubMed citation Europe PMC
19443516 PubMed citation Europe PMC
19815121 PubMed citation Europe PMC
20620250 PubMed citation Europe PMC
Last Modified
22 February 2017