CHEBI:63791 - lenalidomide

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ChEBI Name lenalidomide
ChEBI ID CHEBI:63791
Definition A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-α.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Supplier Information
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Formula C13H13N3O3
Net Charge 0
Average Mass 259.26060
Monoisotopic Mass 259.096
InChI InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChIKey GOTYRUGSSMKFNF-UHFFFAOYSA-N
SMILES Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Application(s): angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
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ChEBI Ontology
Outgoing lenalidomide (CHEBI:63791) has role angiogenesis inhibitor (CHEBI:48422)
lenalidomide (CHEBI:63791) has role antineoplastic agent (CHEBI:35610)
lenalidomide (CHEBI:63791) has role immunomodulator (CHEBI:50846)
lenalidomide (CHEBI:63791) is a aromatic amine (CHEBI:33860)
lenalidomide (CHEBI:63791) is a dicarboximide (CHEBI:35356)
lenalidomide (CHEBI:63791) is a isoindoles (CHEBI:24897)
lenalidomide (CHEBI:63791) is a piperidones (CHEBI:48589)
IUPAC Name
3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
INN Source
lenalidomide KEGG DRUG
Synonyms Sources
1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline ChEBI
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione ChemIDplus
Brand Name Source
Revlimid KEGG DRUG
Manual Xrefs Databases
3317 DrugCentral
D04687 KEGG DRUG
DB00480 DrugBank
Lenalidomide Wikipedia
LSM-6187 LINCS
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Registry Numbers Types Sources
191732-72-6 CAS Registry Number ChemIDplus
8335210 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017