CHEBI:63448 - PD173074

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ChEBI Name PD173074
ChEBI ID CHEBI:63448
Definition A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Bijay
Supplier Information
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Formula C28H41N7O3
Net Charge 0
Average Mass 523.67020
Monoisotopic Mass 523.327
InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
InChIKey DXCUKNQANPLTEJ-UHFFFAOYSA-N
SMILES CCN(CC)CCCCNc1ncc2cc(-c3cc(OC)cc(OC)c3)c(NC(=O)NC(C)(C)C)nc2n1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): fibroblast growth factor receptor antagonist
An antagonist at the fibroblast growth factor receptor.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PD173074 (CHEBI:63448) has role antineoplastic agent (CHEBI:35610)
PD173074 (CHEBI:63448) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
PD173074 (CHEBI:63448) has role fibroblast growth factor receptor antagonist (CHEBI:63457)
PD173074 (CHEBI:63448) is a aromatic amine (CHEBI:33860)
PD173074 (CHEBI:63448) is a biaryl (CHEBI:64459)
PD173074 (CHEBI:63448) is a dimethoxybenzene (CHEBI:51681)
PD173074 (CHEBI:63448) is a pyridopyrimidine (CHEBI:38932)
PD173074 (CHEBI:63448) is a tertiary amino compound (CHEBI:50996)
PD173074 (CHEBI:63448) is a ureas (CHEBI:47857)
IUPAC Name
1-tert-butyl-3-[2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
Synonyms Sources
PD 173074 ChEBI
PD-173074 ChEBI
Manual Xref Database
LSM-1026 LINCS
View more database links
Registry Numbers Types Sources
10130688 Reaxys Registry Number Reaxys
219580-11-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
14598292 PubMed citation Europe PMC
14715624 PubMed citation Europe PMC
14960493 PubMed citation Europe PMC
16448042 PubMed citation Europe PMC
17356708 PubMed citation Europe PMC
19340397 PubMed citation Europe PMC
19903855 PubMed citation Europe PMC
19955487 PubMed citation Europe PMC
Last Modified
24 February 2016
Submitter Remark
2011-12-20 10:41:22.0 Bijay See this link for further details http://chemdea.com/cpds/cd0172.htm