CHEBI:617099 - carbimazole

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ChEBI Name carbimazole
ChEBI ID CHEBI:617099
Definition A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:3397
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Formula C7H10N2O2S
Net Charge 0
Average Mass 186.23100
Monoisotopic Mass 186.046
InChI InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3
InChIKey CFOYWRHIYXMDOT-UHFFFAOYSA-N
SMILES CCOC(=O)n1ccn(C)c1=S
Roles Classification
Biological Role(s): antithyroid drug
A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
Application(s): prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
antithyroid drug
A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
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ChEBI Ontology
Outgoing carbimazole (CHEBI:617099) has role antithyroid drug (CHEBI:50671)
carbimazole (CHEBI:617099) has role prodrug (CHEBI:50266)
carbimazole (CHEBI:617099) is a 1,3-dihydroimidazole-2-thiones (CHEBI:139340)
carbimazole (CHEBI:617099) is a carbamate ester (CHEBI:23003)
IUPAC Name
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
INNs Sources
carbimazol ChemIDplus
carbimazole WHO MedNet
carbimazole ChemIDplus
carbimazolum ChemIDplus
Synonyms Sources
Athyromazole ChemIDplus
Carbethoxymethimazole ChemIDplus
Carbinazole DrugBank
Ethyl 3-methyl-2-thioimidazoline-1-carboxylate ChemIDplus
Thyrostat ChemIDplus
Manual Xrefs Databases
1876 VSDB
497 DrugCentral
C07615 KEGG COMPOUND
Carbimazole Wikipedia
D07616 KEGG DRUG
DB00389 DrugBank
LSM-5930 LINCS
US2671088 Patent
US2815349 Patent
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Registry Numbers Types Sources
0144339 Beilstein Registry Number Beilstein
144339 Reaxys Registry Number Reaxys
22232-54-8 CAS Registry Number KEGG COMPOUND
22232-54-8 CAS Registry Number NIST Chemistry WebBook
22232-54-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1502708 PubMed citation Europe PMC
18954039 PubMed citation ChEMBL
23343442 PubMed citation Europe PMC
23391946 PubMed citation Europe PMC
23776913 PubMed citation Europe PMC
23900475 PubMed citation Europe PMC
24049063 PubMed citation Europe PMC
24255992 PubMed citation Europe PMC
24265129 PubMed citation Europe PMC
25013255 PubMed citation Europe PMC
Last Modified
20 December 2017