CHEBI:59849 - ecothiopate iodide

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ChEBI Name ecothiopate iodide
ChEBI ID CHEBI:59849
Definition The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C9H23INO3PS
Net Charge 0
Average Mass 383.22700
Monoisotopic Mass 383.018
InChI InChI=1S/C9H23NO3PS.HI/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5;/h6-9H2,1-5H3;1H/q+1;/p-1
InChIKey OVXQHPWHMXOFRD-UHFFFAOYSA-M
SMILES [I-].CCOP(=O)(OCC)SCC[N+](C)(C)C
Roles Classification
Biological Role(s): EC 3.1.1.8 (cholinesterase) inhibitor
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
miotic
Aa agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.
Application(s): antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
miotic
Aa agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.
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ChEBI Ontology
Outgoing ecothiopate iodide (CHEBI:59849) has part ecothiopate (CHEBI:4753)
ecothiopate iodide (CHEBI:59849) has role antiglaucoma drug (CHEBI:39456)
ecothiopate iodide (CHEBI:59849) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733)
ecothiopate iodide (CHEBI:59849) has role miotic (CHEBI:51068)
ecothiopate iodide (CHEBI:59849) is a iodide salt (CHEBI:24858)
ecothiopate iodide (CHEBI:59849) is a quaternary ammonium salt (CHEBI:35273)
IUPAC Name
2-[(diethoxyphosphoryl)sulfanyl]-N,N,N-trimethylethanaminium iodide
INNs Sources
ecothiopate iodide KEGG DRUG
ecothiopati iodidum ChemIDplus
iodure d'ecothiopate ChemIDplus
ioduro de ecotiopato ChemIDplus
Synonyms Sources
(2-mercaptoethyl)trimethylammonium iodidie O,O-diethyl phosphorothioate ChEBI
2-[(diethoxyphosphinyl)thio]-N,N,N-trimethylethanaminium iodide ChEBI
2-diethoxy-phosphinylthioethyl-trimethylammonium iodide ChemIDplus
diethoxyphosphinylthiocholine iodide ChEBI
diethoxyphosphoryl-thiocholine iodide ChemIDplus
ecothiophate iodide ChemIDplus
N-(2-(diethoxyphosphinylthio)ethyl)trimethylammonium iodide ChemIDplus
O,O-diethyl S-2-trimethylammonium ethylphosphonothiolate iodide ChemIDplus
S-(2-(N,N,N-trimethylammonio)ethyl) O,O-diethylphosphorothiolate iodide ChemIDplus
S-(2-dimethylaminoethyl)-O,O-diethylphosphorothioate methiodide ChemIDplus
S-β-dimethylaminoethyl-O,O-diethylthionophosphate methiodide ChEBI
Database Links Databases
D02193 KEGG DRUG
DB01057 DrugBank
US2911430 Patent
View more database links
Registry Numbers Types Sources
3762945 Beilstein Registry Number Beilstein
513-10-0 CAS Registry Number ChemIDplus
513-10-0 CAS Registry Number KEGG DRUG
Last Modified
26 July 2010