CHEBI:57453 - (6S)-5,6,7,8-tetrahydrofolate(2−)

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ChEBI Name (6S)-5,6,7,8-tetrahydrofolate(2−)
ChEBI ID CHEBI:57453
ChEBI ASCII Name (6S)-5,6,7,8-tetrahydrofolate(2-)
Definition Dianion of (6S)-5,6,7,8-tetrahydrofolic acid arising from deprotonation of both carboxylic acid functions.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C19H21N7O6
Net Charge -2
Average Mass 443.41330
Monoisotopic Mass 443.155
InChI InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1
InChIKey MSTNYGQPCMXVAQ-RYUDHWBXSA-L
SMILES Nc1nc2NC[C@H](CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)Nc2c(=O)[nH]1
Metabolite of Species Details
Homo sapiens (NCBI:txid9606) See: DOI
Roles Classification
Biological Role(s): human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
View more via ChEBI Ontology
ChEBI Ontology
Outgoing (6S)-5,6,7,8-tetrahydrofolate(2−) (CHEBI:57453) has role human metabolite (CHEBI:77746)
(6S)-5,6,7,8-tetrahydrofolate(2−) (CHEBI:57453) is a dicarboxylic acid dianion (CHEBI:28965)
(6S)-5,6,7,8-tetrahydrofolate(2−) (CHEBI:57453) is conjugate base of (6S)-5,6,7,8-tetrahydrofolic acid (CHEBI:15635)
Incoming (6S)-5,6,7,8-tetrahydrofolic acid (CHEBI:15635) is conjugate acid of (6S)-5,6,7,8-tetrahydrofolate(2−) (CHEBI:57453)
IUPAC Name
N-[4-({[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamate
Synonyms Sources
(6S)-5,6,7,8-tetrahydrofolate UniProt
(6S)-5,6,7,8-tetrahydrofolate dianion ChEBI
Registry Number Type Source
10223255 Beilstein Registry Number Beilstein
Last Modified
10 March 2014