CHEBI:51380 - doxylamine

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ChEBI Name doxylamine
ChEBI ID CHEBI:51380
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H22N2O
Net Charge 0
Average Mass 270.36946
Monoisotopic Mass 270.173
InChI InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
InChIKey HCFDWZZGGLSKEP-UHFFFAOYSA-N
SMILES CN(C)CCOC(C)(c1ccccc1)c1ccccn1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
antitussive
An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
anti-allergic agent
A drug used to treat allergic reactions.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing doxylamine (CHEBI:51380) has role anti-allergic agent (CHEBI:50857)
doxylamine (CHEBI:51380) has role antiemetic (CHEBI:50919)
doxylamine (CHEBI:51380) has role antitussive (CHEBI:51177)
doxylamine (CHEBI:51380) has role cholinergic antagonist (CHEBI:48873)
doxylamine (CHEBI:51380) has role H1-receptor antagonist (CHEBI:37955)
doxylamine (CHEBI:51380) has role histamine antagonist (CHEBI:37956)
doxylamine (CHEBI:51380) has role sedative (CHEBI:35717)
doxylamine (CHEBI:51380) is a pyridines (CHEBI:26421)
doxylamine (CHEBI:51380) is a tertiary amine (CHEBI:32876)
IUPAC Name
N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
INNs Sources
doxilamina WHO MedNet
doxylamine WHO MedNet
doxylamine KEGG DRUG
doxylaminum WHO MedNet
Synonyms Sources
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine ChemIDplus
2-Dimethylaminoethoxyphenylmethyl-2-picoline ChemIDplus
Dossilamina ChemIDplus
Doxilminio ChemIDplus
N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine ChemIDplus
Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether ChemIDplus
Manual Xrefs Databases
962 DrugCentral
D07878 KEGG DRUG
DB00366 DrugBank
Doxylamine Wikipedia
LSM-1563 LINCS
View more database links
Registry Numbers Types Sources
230379 Beilstein Registry Number Beilstein
469-21-6 CAS Registry Number ChemIDplus
Last Modified
22 February 2017