CHEBI:5137 - fluvastatin sodium

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ChEBI Name fluvastatin sodium
Definition A racemate that is the sodium salt of fluvastatin. An HMG-CoA reductase inhibitor, it is used to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): EC (anthrax lethal factor endopeptidase) inhibitor
An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC
EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
(via statin )
Application(s): antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
anticholesteremic drug
A substance used to lower plasma cholesterol levels.
(via statin )
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ChEBI Ontology
Outgoing fluvastatin sodium (CHEBI:5137) has part (3R,5S)-fluvastatin sodium (CHEBI:77602)
fluvastatin sodium (CHEBI:5137) has part (3S,5R)-fluvastatin sodium (CHEBI:77603)
fluvastatin sodium (CHEBI:5137) has role antilipemic drug (CHEBI:35679)
fluvastatin sodium (CHEBI:5137) has role EC (anthrax lethal factor endopeptidase) inhibitor (CHEBI:77255)
fluvastatin sodium (CHEBI:5137) is a racemate (CHEBI:60911)
fluvastatin sodium (CHEBI:5137) is a statin (synthetic) (CHEBI:87635)
rac-sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
Synonyms Sources
(±)-fluvastatin sodium ChEBI
(±)-sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate ChEBI
sodium (±)-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate ChEBI
XU-62-320 ChEBI
Brand Names Sources
Lipaxan ChemIDplus
Locol ChemIDplus
Lymetel ChemIDplus
Primesin ChemIDplus
Vastin ChemIDplus
Manual Xrefs Databases
DB01095 DrugBank
EP1825847 Patent
View more database links
Registry Numbers Types Sources
6630711 Reaxys Registry Number Reaxys
93957-55-2 CAS Registry Number KEGG DRUG
93957-55-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10037456 PubMed citation Europe PMC
10823666 PubMed citation Europe PMC
11273020 PubMed citation Europe PMC
11939635 PubMed citation Europe PMC
20064114 PubMed citation Europe PMC
23033850 PubMed citation Europe PMC
7492622 PubMed citation Europe PMC
8104114 PubMed citation Europe PMC
8466953 PubMed citation Europe PMC
Last Modified
24 August 2015