CHEBI:51364 - zuclopenthixol

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name zuclopenthixol
ChEBI ID CHEBI:51364
Definition The (Z)-isomer of clopenthixol.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C22H25ClN2OS
Net Charge 0
Average Mass 400.96548
Monoisotopic Mass 400.13761
InChI InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5-
InChIKey WFPIAZLQTJBIFN-DVZOWYKESA-N
SMILES OCCN1CCN(CC\C=C2\c3ccccc3Sc3ccc(Cl)cc23)CC1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
(via clopenthixol )
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
(via clopenthixol )
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
(via clopenthixol )
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
(via clopenthixol )
Application(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
(via clopenthixol )
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
(via clopenthixol )
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
(via clopenthixol )
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
(via clopenthixol )
first generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased.
(via clopenthixol )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing zuclopenthixol (CHEBI:51364) has role α-adrenergic antagonist (CHEBI:37890)
zuclopenthixol (CHEBI:51364) has role dopaminergic antagonist (CHEBI:48561)
zuclopenthixol (CHEBI:51364) has role first generation antipsychotic (CHEBI:65190)
zuclopenthixol (CHEBI:51364) has role H1-receptor antagonist (CHEBI:37955)
zuclopenthixol (CHEBI:51364) has role serotonergic antagonist (CHEBI:48279)
zuclopenthixol (CHEBI:51364) is a clopenthixol (CHEBI:59115)
IUPAC Name
2-{4-[(3Z)-3-(2-chloro-10H-dibenzo[b,e]thiopyran-10-ylidene)propyl]piperazin-1-yl}ethanol
INNs Sources
zuclopenthixol WHO MedNet
zuclopenthixol ChemIDplus
zuclopenthixolum WHO MedNet
zuclopentixol WHO MedNet
Synonym Source
(Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol ChemIDplus
Manual Xrefs Databases
2877 DrugCentral
D03556 KEGG DRUG
DB01624 DrugBank
View more database links
Registry Numbers Types Sources
53772-83-1 CAS Registry Number ChemIDplus
8447014 Beilstein Registry Number Beilstein
Last Modified
22 February 2017