CHEBI:50268 - GABA modulator

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name GABA modulator
ChEBI ID CHEBI:50268
Definition A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Stars This entity has been manually annotated by the ChEBI Team.
ChEBI Ontology
Outgoing GABA modulator (CHEBI:50268) is a GABA agent (CHEBI:51374)
GABA modulator (CHEBI:50268) is a membrane transport modulator (CHEBI:38632)
Incoming α-asarone (CHEBI:78309) has role GABA modulator (CHEBI:50268)
β-asarone (CHEBI:10353) has role GABA modulator (CHEBI:50268)
barbiturates (CHEBI:22693) has role GABA modulator (CHEBI:50268)
benzodiazepine (CHEBI:22720) has role GABA modulator (CHEBI:50268)
brexanolone (CHEBI:50169) has role GABA modulator (CHEBI:50268)
clobazam (CHEBI:31413) has role GABA modulator (CHEBI:50268)
clonazepam (CHEBI:3756) has role GABA modulator (CHEBI:50268)
clorazepic acid (CHEBI:3761) has role GABA modulator (CHEBI:50268)
dipotassium clorazepate (CHEBI:3762) has role GABA modulator (CHEBI:50268)
estazolam (CHEBI:4858) has role GABA modulator (CHEBI:50268)
isoliquiritigenin (CHEBI:310312) has role GABA modulator (CHEBI:50268)
nimetazepam (CHEBI:31912) has role GABA modulator (CHEBI:50268)
nitrazepam (CHEBI:7581) has role GABA modulator (CHEBI:50268)
nordazepam (CHEBI:111762) has role GABA modulator (CHEBI:50268)
pinocarveol (CHEBI:26137) has role GABA modulator (CHEBI:50268)
secobarbital (CHEBI:9073) has role GABA modulator (CHEBI:50268)
secobarbital sodium (CHEBI:32124) has role GABA modulator (CHEBI:50268)
valerenic acid (CHEBI:9921) has role GABA modulator (CHEBI:50268)
verruculogen (CHEBI:72765) has role GABA modulator (CHEBI:50268)
Synonym Source
GABA modulators ChEBI
Last Modified
31 March 2019