CHEBI:48574 - phenylbutazone

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name phenylbutazone
Definition A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:44635, CHEBI:8091
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C19H20N2O2
Net Charge 0
Average Mass 308.37430
Monoisotopic Mass 308.15248
InChI InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
SMILES CCCCC1C(=O)N(N(C1=O)c1ccccc1)c1ccccc1
Roles Classification
Biological Role(s): EC [carbonyl reductase (NADPH)] inhibitor
An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of carbonyl reductase (NADPH), EC
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
peripheral nervous system drug
A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing phenylbutazone (CHEBI:48574) has role antirheumatic drug (CHEBI:35842)
phenylbutazone (CHEBI:48574) has role EC [carbonyl reductase (NADPH)] inhibitor (CHEBI:73136)
phenylbutazone (CHEBI:48574) has role metabolite (CHEBI:25212)
phenylbutazone (CHEBI:48574) has role non-narcotic analgesic (CHEBI:35481)
phenylbutazone (CHEBI:48574) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
phenylbutazone (CHEBI:48574) has role peripheral nervous system drug (CHEBI:49110)
phenylbutazone (CHEBI:48574) is a pyrazolidines (CHEBI:38312)
Incoming kebuzone (CHEBI:31749) has functional parent phenylbutazone (CHEBI:48574)
oxyphenbutazone (CHEBI:76258) has functional parent phenylbutazone (CHEBI:48574)
INNs Sources
fenilbutazona ChemIDplus
phenylbutazone ChemIDplus
phénylbutazone WHO MedNet
phenylbutazonum ChemIDplus
Synonyms Sources
3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine ChemIDplus
4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione ChemIDplus
Phenbutazone KEGG COMPOUND
Phenylbutazon ChemIDplus
Phenylbutazone KEGG COMPOUND
Manual Xrefs Databases
1775 VSDB
2145 DrugCentral
DB00812 DrugBank
HMDB0014950 HMDB
P1Z PDBeChem
Phenylbutazone Wikipedia
View more database links
Registry Numbers Types Sources
290080 Beilstein Registry Number Beilstein
290080 Reaxys Registry Number Reaxys
50-33-9 CAS Registry Number KEGG COMPOUND
Citations Waiting for Citations Types Sources
11264893 PubMed citation Europe PMC
12692637 PubMed citation Europe PMC
13010905 PubMed citation Europe PMC
13048452 PubMed citation Europe PMC
13747451 PubMed citation Europe PMC
19614844 PubMed citation Europe PMC
20176071 PubMed citation Europe PMC
21668837 PubMed citation Europe PMC
22082440 PubMed citation Europe PMC
22180948 PubMed citation Europe PMC
22245664 PubMed citation Europe PMC
23369749 PubMed citation Europe PMC
23525812 PubMed citation Europe PMC
25287371 PubMed citation Europe PMC
26090772 PubMed citation Europe PMC
26808199 PubMed citation Europe PMC
3425858 PubMed citation Europe PMC
7655439 PubMed citation Europe PMC
Last Modified
22 February 2017