CHEBI:47426 - furosemide

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name furosemide
Definition A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:47425, CHEBI:5198
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Formula C12H11ClN2O5S
Net Charge 0
Average Mass 330.74400
Monoisotopic Mass 330.00772
InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
SMILES NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Application(s): loop diuretic
A diuretic that acts on the ascending loop of Henle in the kidney.
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ChEBI Ontology
Outgoing furosemide (CHEBI:47426) has role environmental contaminant (CHEBI:78298)
furosemide (CHEBI:47426) has role loop diuretic (CHEBI:77608)
furosemide (CHEBI:47426) has role xenobiotic (CHEBI:35703)
furosemide (CHEBI:47426) is a chlorobenzoic acid (CHEBI:23134)
furosemide (CHEBI:47426) is a furans (CHEBI:24129)
furosemide (CHEBI:47426) is a sulfonamide (CHEBI:35358)
4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid
Synonyms Sources
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid ChemIDplus
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid ChemIDplus
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid ChemIDplus
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid ChemIDplus
Frusemide KEGG DRUG
Furosemide KEGG DRUG
Manual Xrefs Databases
1258 DrugCentral
1770 VSDB
DB00695 DrugBank
Furosemide Wikipedia
HMDB0001933 HMDB
View more database links
Registry Numbers Types Sources
1399731 Reaxys Registry Number Reaxys
54-31-9 CAS Registry Number ChemIDplus
54-31-9 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
15286542 PubMed citation Europe PMC
18701232 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag