CHEBI:47097 - lonafarnib

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ChEBI Name lonafarnib
Definition A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C27H31Br2ClN4O2
Net Charge 0
Average Mass 638.822
Monoisotopic Mass 636.05023
InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
Roles Classification
Biological Role(s): EC (protein farnesyltransferase) inhibitor
An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein farnesyltransferase (EC, one of the three enzymes in the prenyltransferase group.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing lonafarnib (CHEBI:47097) has role antineoplastic agent (CHEBI:35610)
lonafarnib (CHEBI:47097) has role EC (protein farnesyltransferase) inhibitor (CHEBI:64133)
lonafarnib (CHEBI:47097) is a 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide (CHEBI:90678)
INNs Sources
lonafarnib WHO MedNet
lonafarnib WHO MedNet
lonafarnib WHO MedNet
lonafarnibum WHO MedNet
Synonym Source
SCH 66336 ChEBI
Manual Xrefs Databases
336 PDBeChem
Lonafarnib Wikipedia
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Registry Numbers Types Sources
193275-84-2 CAS Registry Number ChemIDplus
8244925 Reaxys Registry Number Reaxys
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Last Modified
21 April 2016