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InChI=1S/CH4O/c1-2/h2H,1H3
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ChEBI
> Main
CHEBI:46024 - trichostatin A
Main
ChEBI Ontology
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ChEBI Name
trichostatin A
ChEBI ID
CHEBI:46024
Stars
This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs
CHEBI:39145, CHEBI:46022
Supplier Information
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Read full article at Wikipedia
Formula
C17H22N2O3
Net Charge
0
Average Mass
302.36826
Monoisotopic Mass
302.16304
InChI
InChI=1S/C17H22N2O3/c1-
12(5-
10-
16(20)
18-
22)
11-
13(2)
17(21)
14-
6-
8-
15(9-
7-
14)
19(3)
4/h5-
11,13,22H,1-
4H3,(H,18,20)
/b10-
5+,12-
11+/t13-
/m1/s1
InChIKey
RTKIYFITIVXBLE-QEQCGCAPSA-N
SMILES
C[C@@H](C(=O)c1ccc(cc1)N(C)C)\C=C(C)\C=C\C(=O)NO
Metabolite of Species
Details
Streptomyces hygroscopicus
(NCBI:txid1912)
See:
PubMed
Roles Classification
Biological Role
(s):
bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
(via
antibiotic antifungal agent
)
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via
carbocyclic antibiotic
)
Application
(s):
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
trichostatin A (
CHEBI:46024
)
has functional parent
(
R
)-trichostatic acid (
CHEBI:39158
)
trichostatin A (
CHEBI:46024
)
has role
bacterial metabolite (
CHEBI:76969
)
trichostatin A (
CHEBI:46024
)
has role
EC 3.5.1.98 (histone deacetylase) inhibitor (
CHEBI:61115
)
trichostatin A (
CHEBI:46024
)
has role
geroprotector (
CHEBI:176497
)
trichostatin A (
CHEBI:46024
)
is a
antibiotic antifungal agent (
CHEBI:86478
)
trichostatin A (
CHEBI:46024
)
is a
hydroxamic acid (
CHEBI:24650
)
trichostatin A (
CHEBI:46024
)
is a
trichostatin (
CHEBI:39146
)
Incoming
trichostatin C (
CHEBI:39147
)
has functional parent
trichostatin A (
CHEBI:46024
)
trichostatin D (
CHEBI:39160
)
has functional parent
trichostatin A (
CHEBI:46024
)
IUPAC Name
(2
E
,4
E
,6
R
)-
7-
[4-
(dimethylamino)phenyl]-
N
-
hydroxy-
4,6-
dimethyl-
7-
oxohepta-
2,4-
dienamide
Synonyms
Sources
(2
E
,4
E
,6
R
)-
7-
(4-
(dimethylamino)phenyl)-
N
-
hydroxy-
4,6-
dimethyl-
7-
oxo-
2,4-
heptadienamide
ChemIDplus
TRICHOSTATIN A
PDBeChem
TSA
ChemIDplus
Manual Xrefs
Databases
C00016002
KNApSAcK
DB04297
DrugBank
HMDB0259177
HMDB
Trichostatin_A
Wikipedia
TSN
PDBeChem
View more database links
Registry Numbers
Types
Sources
5291761
Beilstein Registry Number
Beilstein
58880-19-6
CAS Registry Number
ChemIDplus
Citations
Types
Sources
10490031
PubMed citation
Europe PMC
15346199
PubMed citation
Europe PMC
16010430
PubMed citation
Europe PMC
18285338
PubMed citation
Europe PMC
19038231
PubMed citation
Europe PMC
21504214
PubMed citation
Europe PMC
25075551
PubMed citation
Europe PMC
27454931
PubMed citation
Europe PMC
30395713
PubMed citation
Europe PMC
31755702
PubMed citation
Europe PMC
32880591
PubMed citation
Europe PMC
33983895
PubMed citation
Europe PMC
34086940
PubMed citation
Europe PMC
Last Modified
27 October 2021