CHEBI:41774 - tamoxifen

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name tamoxifen
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:41767, CHEBI:9396
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Formula C26H29NO
Net Charge 0
Average Mass 371.51460
Monoisotopic Mass 371.22491
InChI InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
SMILES CC\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): estrogen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
EC (aldehyde oxidase) inhibitor
An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC
estrogen receptor antagonist
An antagonist at the estrogen receptor.
EC (protein kinase C) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC
Application(s): estrogen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
estrogen receptor modulator
A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure.
bone density conservation agent
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
estrogen receptor antagonist
An antagonist at the estrogen receptor.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tamoxifen (CHEBI:41774) has parent hydride stilbene (CHEBI:26775)
tamoxifen (CHEBI:41774) has role angiogenesis inhibitor (CHEBI:48422)
tamoxifen (CHEBI:41774) has role antineoplastic agent (CHEBI:35610)
tamoxifen (CHEBI:41774) has role bone density conservation agent (CHEBI:50646)
tamoxifen (CHEBI:41774) has role EC (aldehyde oxidase) inhibitor (CHEBI:62872)
tamoxifen (CHEBI:41774) has role EC (protein kinase C) inhibitor (CHEBI:37700)
tamoxifen (CHEBI:41774) has role estrogen antagonist (CHEBI:50837)
tamoxifen (CHEBI:41774) has role estrogen receptor antagonist (CHEBI:50792)
tamoxifen (CHEBI:41774) has role estrogen receptor modulator (CHEBI:50739)
tamoxifen (CHEBI:41774) is a stilbenoid (CHEBI:26776)
tamoxifen (CHEBI:41774) is a tertiary amino compound (CHEBI:50996)
Incoming afimoxifene (CHEBI:44616) has functional parent tamoxifen (CHEBI:41774)
tamoxifen N-oxide (CHEBI:63825) has functional parent tamoxifen (CHEBI:41774)
tamoxifen citrate (CHEBI:9397) has part tamoxifen (CHEBI:41774)
INNs Sources
tamoxifen ChemIDplus
tamoxifène ChemIDplus
tamoxifeno ChemIDplus
tamoxifenum ChemIDplus
Synonyms Sources
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine ChemIDplus
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine ChemIDplus
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene ChemIDplus
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene ChemIDplus
trans-Tamoxifen ChemIDplus
Brand Names Sources
Apo-Tamox DrugBank
Citofen Deprecated term DrugBank
Crisafeno DrugBank
Diemon DrugBank
Gen-Tamoxifen Deprecated term DrugBank
Istubol Deprecated term DrugBank
Noltam Deprecated term DrugBank
Nourytam Deprecated term DrugBank
Oncomox Deprecated term DrugBank
Retaxim Deprecated term DrugBank
Tamofen Deprecated term DrugBank
Tamone Deprecated term DrugBank
Tamoxasta Deprecated term DrugBank
Valodex Deprecated term DrugBank
Zemide Deprecated term DrugBank
Manual Xrefs Databases
2561 DrugCentral
BE637389 Patent
BE678807 Patent
DB00675 DrugBank
HMDB0014813 HMDB
Tamoxifen Wikipedia
US4536516 Patent
View more database links
Registry Numbers Types Sources
10540-29-1 CAS Registry Number ChemIDplus
2062020 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
14681337 PubMed citation Europe PMC
14709804 PubMed citation Europe PMC
18348622 PubMed citation Europe PMC
7688593 PubMed citation Europe PMC
Last Modified
22 February 2017