CHEBI:38940 - sunitinib

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ChEBI Name sunitinib
ChEBI ID CHEBI:38940
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H27FN4O2
Net Charge 0
Average Mass 398.47380
Monoisotopic Mass 398.212
InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
InChIKey WINHZLLDWRZWRT-ATVHPVEESA-N
SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Roles Classification
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Application(s): angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
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ChEBI Ontology
Outgoing sunitinib (CHEBI:38940) has functional parent 3-methyleneoxindole (CHEBI:17920)
sunitinib (CHEBI:38940) has role angiogenesis inhibitor (CHEBI:48422)
sunitinib (CHEBI:38940) has role antineoplastic agent (CHEBI:35610)
sunitinib (CHEBI:38940) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
sunitinib (CHEBI:38940) has role immunomodulator (CHEBI:50846)
sunitinib (CHEBI:38940) has role neuroprotective agent (CHEBI:63726)
sunitinib (CHEBI:38940) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
sunitinib (CHEBI:38940) is a monocarboxylic acid amide (CHEBI:29347)
sunitinib (CHEBI:38940) is a pyrroles (CHEBI:26455)
Incoming linkable sunitinib analogue (CHEBI:39081) has functional parent sunitinib (CHEBI:38940)
IUPAC Name
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
INNs Sources
sunitinib ChEBI
sunitinibum ChEBI
Synonyms Sources
SU-11248 ChEBI
Sunitinib ChemIDplus
Sutent ChemIDplus
Manual Xrefs Databases
2544 DrugCentral
DB01268 DrugBank
HMDB0015397 HMDB
Sunitinib Wikipedia
View more database links
Registry Number Type Source
557795-19-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
12531805 PubMed citation Europe PMC
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Last Modified
22 February 2017