CHEBI:37941 - clopidogrel

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ChEBI Name clopidogrel
Definition A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
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Formula C16H16ClNO2S
Net Charge 0
Average Mass 321.82200
Monoisotopic Mass 321.05903
InChI InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
SMILES COC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl
Roles Classification
Biological Role(s): P2Y12 receptor antagonist
An antagonist at the P2Y12 receptor
Application(s): platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
An agent that prevents blood clotting.
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ChEBI Ontology
Outgoing clopidogrel (CHEBI:37941) has functional parent ticlopidine (CHEBI:9588)
clopidogrel (CHEBI:37941) has role anticoagulant (CHEBI:50249)
clopidogrel (CHEBI:37941) has role P2Y12 receptor antagonist (CHEBI:68563)
clopidogrel (CHEBI:37941) has role platelet aggregation inhibitor (CHEBI:50427)
clopidogrel (CHEBI:37941) is a methyl ester (CHEBI:25248)
clopidogrel (CHEBI:37941) is a monochlorobenzenes (CHEBI:83403)
clopidogrel (CHEBI:37941) is a thienopyridine (CHEBI:37942)
Incoming clopidogrel sulfate (CHEBI:3759) has part clopidogrel (CHEBI:37941)
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
INNs Sources
clopidogrel WHO MedNet
clopidogrel WHO MedNet
clopidogrel WHO MedNet
clopidogrelum ChemIDplus
Synonym Source
(+)-Clopidogrel ChEBI
Manual Xrefs Databases
708 DrugCentral
Clopidogrel Wikipedia
DB00758 DrugBank
EP281459 Patent
EP99802 Patent
US4529596 Patent
US4847265 Patent
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Registry Numbers Types Sources
113665-84-2 CAS Registry Number ChemIDplus
8151914 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
10983738 PubMed citation Europe PMC
11095576 PubMed citation Europe PMC
11701941 PubMed citation Europe PMC
16802846 PubMed citation Europe PMC
18520712 PubMed citation Europe PMC
18708826 PubMed citation Europe PMC
19573725 PubMed citation Europe PMC
Last Modified
22 February 2017