CHEBI:3770 - co-trimoxazole

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ChEBI Name co-trimoxazole
Definition A two-component mixture comprising trimethoprim and sulfamethoxazole.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): drug allergen
Any drug which causes the onset of an allergic reaction.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antibacterial drug
A drug used to treat or prevent bacterial infections.
Application(s): drug allergen
Any drug which causes the onset of an allergic reaction.
antibacterial drug
A drug used to treat or prevent bacterial infections.
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ChEBI Ontology
Outgoing co-trimoxazole (CHEBI:3770) has part sulfamethoxazole (CHEBI:9332)
co-trimoxazole (CHEBI:3770) has part trimethoprim (CHEBI:45924)
co-trimoxazole (CHEBI:3770) has role antibacterial drug (CHEBI:36047)
co-trimoxazole (CHEBI:3770) has role antimicrobial agent (CHEBI:33281)
co-trimoxazole (CHEBI:3770) has role drug allergen (CHEBI:88188)
co-trimoxazole (CHEBI:3770) is a mixture (CHEBI:60004)
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide - 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1)
Synonyms Sources
Cotrimoxazol ChemIDplus
Cotrimoxazole ChemIDplus
sulfamethoxazol/trimetoprim ChEBI
Sulfamethoxazole - trimethoprim mixture KEGG DRUG
Sulfamethoxazole / trimethoprim ChemIDplus
Sulfamethoxazole and trimethoprim ChemIDplus
Sulfamethoxazole mixture with trimethoprim ChemIDplus
Sulfamethoxazole trimethoprim ChemIDplus
Sulfamethoxazole-trimethoprim ChemIDplus
Trimethoprim and sulfamethoxazole ChemIDplus
Trimethoprim and sulphamethoxazole ChemIDplus
Trimethoprim-sulfamethoxazole KEGG DRUG
Trimethoprim-sulfamethoxazole combination ChemIDplus
Trimethoprim/sulfamethoxazole ChemIDplus
Brand Names Sources
Bactrim ChEBI
Septra ChEBI
Manual Xrefs Databases
Trimethoprim/sulfamethoxazole Wikipedia
View more database links
Registry Numbers Types Sources
5236098 Reaxys Registry Number Reaxys
8064-90-2 CAS Registry Number ChemIDplus
8064-90-2 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
10737909 PubMed citation Europe PMC
11120976 PubMed citation Europe PMC
445303 PubMed citation Europe PMC
9756768 PubMed citation Europe PMC
Last Modified
15 October 2015
General Comments
2011-04-12 The trimethoprim-sulfamethoxazole combination, usually employed in the ratio 1:5 has broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. Although it was claimed to be more effective than either of its components individually, this has been disputed, and its use is frequently restricted to specific cases where its improved efficacy has been demonstrated. It is used in the treatment of a variety of bacterial infections, including those caused by by Listeria monocytogenes, Nocardia spp., and Stenotrophomonas maltophilia.
2011-04-12 .