CHEBI:3756 - clonazepam

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ChEBI Name clonazepam
ChEBI ID CHEBI:3756
Definition 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:102465
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Formula C15H10ClN3O3
Net Charge 0
Average Mass 315.71100
Monoisotopic Mass 315.04107
InChI InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
InChIKey DGBIGWXXNGSACT-UHFFFAOYSA-N
SMILES [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing clonazepam (CHEBI:3756) has role anticonvulsant (CHEBI:35623)
clonazepam (CHEBI:3756) has role anxiolytic drug (CHEBI:35474)
clonazepam (CHEBI:3756) has role GABA modulator (CHEBI:50268)
clonazepam (CHEBI:3756) is a 1,4-benzodiazepinone (CHEBI:35500)
clonazepam (CHEBI:3756) is a monochlorobenzenes (CHEBI:83403)
IUPAC Name
5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
INNs Sources
clonazepam ChemIDplus
clonazepamum ChemIDplus
Synonyms Sources
1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one ChemIDplus
5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one ChEMBL
5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one ChEMBL
5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one ChemIDplus
CLONAZEPAM ChEMBL
Manual Xrefs Databases
703 DrugCentral
Clonazepam Wikipedia
D00280 KEGG DRUG
DB01068 DrugBank
US3116203 Patent
US3121076 Patent
US3335181 Patent
View more database links
Registry Numbers Types Sources
1622-61-3 CAS Registry Number KEGG DRUG
1622-61-3 CAS Registry Number ChemIDplus
759557 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
10633040 PubMed citation ChEMBL
12213069 PubMed citation ChEMBL
12873507 PubMed citation ChEMBL
Last Modified
22 February 2017