CHEBI:3559 - cerivastatin sodium

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name cerivastatin sodium
Definition The sodium salt of cerivastatin. Formerly used to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C26H33FNNaO5
Net Charge 0
Average Mass 481.53210
Monoisotopic Mass 481.22405
InChI InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1
SMILES [Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c1ccc(F)cc1)C(C)C
Roles Classification
Biological Role(s): EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
(via statin )
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
(via statin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing cerivastatin sodium (CHEBI:3559) has part cerivastatin(1−) (CHEBI:406059)
cerivastatin sodium (CHEBI:3559) is a organic sodium salt (CHEBI:38700)
cerivastatin sodium (CHEBI:3559) is a statin (synthetic) (CHEBI:87635)
sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate
Synonym Source
(+)-sodium (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoate ChemIDplus
Manual Xrefs Databases
DB00439 DrugBank
US5177080 Patent
View more database links
Registry Numbers Types Sources
143201-11-0 CAS Registry Number ChemIDplus
8466341 Beilstein Registry Number Beilstein
Last Modified
24 August 2015