CHEBI:355510 - cefotiam

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ChEBI Name cefotiam
ChEBI ID CHEBI:355510
Definition A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalosporin antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C18H23N9O4S3
Net Charge 0
Average Mass 525.62800
Monoisotopic Mass 525.104
InChI InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
InChIKey QYQDKDWGWDOFFU-IUODEOHRSA-N
SMILES [H][C@]12SCC(CSc3nnnn3CCN(C)C)=C(N1C(=O)[C@@]2([H])NC(=O)Cc1csc(N)n1)C(O)=O
Roles Classification
Biological Role(s): antibacterial drug
A drug used to treat or prevent bacterial infections.
drug allergen
Any drug which causes the onset of an allergic reaction.
(via cephalosporin )
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via heterocyclic antibiotic )
Application(s): antibacterial drug
A drug used to treat or prevent bacterial infections.
drug allergen
Any drug which causes the onset of an allergic reaction.
(via cephalosporin )
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ChEBI Ontology
Outgoing cefotiam (CHEBI:355510) has role antibacterial drug (CHEBI:36047)
cefotiam (CHEBI:355510) is a cephalosporin (CHEBI:23066)
cefotiam (CHEBI:355510) is a semisynthetic derivative (CHEBI:72588)
Incoming cefotiam hexetil dihydrochloride (CHEBI:31373) has functional parent cefotiam (CHEBI:355510)
cefotiam hexetil ester (CHEBI:59211) has functional parent cefotiam (CHEBI:355510)
cefotiam dihydrochloride (CHEBI:31374) has part cefotiam (CHEBI:355510)
IUPAC Names
(6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7β-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic acid
INNs Sources
cefotiam ChemIDplus
cefotiamum ChemIDplus
Synonyms Sources
(6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid ChEMBL
CEFOTIAM ChEMBL
CTM ChEBI
Manual Xrefs Databases
548 DrugCentral
Cefotiam Wikipedia
D07648 KEGG DRUG
DB00229 DrugBank
DE2458695 Patent
LSM-2022 LINCS
US4080498 Patent
View more database links
Registry Number Type Source
61622-34-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
28543395 PubMed citation Europe PMC
6341590 PubMed citation ChEMBL
Last Modified
18 July 2017