CHEBI:34892 - nocodazole

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ChEBI Name nocodazole
ChEBI ID CHEBI:34892
Definition A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C14H11N3O3S
Net Charge 0
Average Mass 301.32000
Monoisotopic Mass 301.052
InChI InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChIKey KYRVNWMVYQXFEU-UHFFFAOYSA-N
SMILES COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1cccs1
Roles Classification
Biological Role(s): tubulin modulator
Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
antimitotic
Any compound that inhibits cell division (mitosis).
microtubule-destabilising agent
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing nocodazole (CHEBI:34892) has role antimitotic (CHEBI:64911)
nocodazole (CHEBI:34892) has role antineoplastic agent (CHEBI:35610)
nocodazole (CHEBI:34892) has role microtubule-destabilising agent (CHEBI:61951)
nocodazole (CHEBI:34892) has role tubulin modulator (CHEBI:60832)
nocodazole (CHEBI:34892) is a aromatic ketone (CHEBI:76224)
nocodazole (CHEBI:34892) is a benzimidazoles (CHEBI:22715)
nocodazole (CHEBI:34892) is a carbamate ester (CHEBI:23003)
nocodazole (CHEBI:34892) is a thiophenes (CHEBI:26961)
IUPAC Name
methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
INNs Sources
nocodazol ChemIDplus
nocodazole KEGG DRUG
nocodazole WHO MedNet
nocodazolum ChemIDplus
Synonyms Sources
(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester ChemIDplus
methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate ChemIDplus
methyl N-(5-thenoyl-2-benzimidazolyl)carbamate NIST Chemistry WebBook
N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl ester ChemIDplus
N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl ester NIST Chemistry WebBook
oncodazole ChemIDplus
R 17934 ChemIDplus
R-17934 ChEBI
R17,934 ChemIDplus
Manual Xrefs Databases
C13719 KEGG COMPOUND
D05197 KEGG DRUG
DB08313 DrugBank
LSM-2260 LINCS
Nocodazole Wikipedia
NZO PDBeChem
View more database links
Registry Numbers Types Sources
1085978 Beilstein Registry Number Beilstein
1085978 Reaxys Registry Number Reaxys
31430-18-9 CAS Registry Number NIST Chemistry WebBook
31430-18-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
24 February 2016