CHEBI:34673 - devapamil

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ChEBI Name devapamil
Definition A nitrile that acts as an L-type calcium channel blocker.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C26H36N2O3
Net Charge 0
Average Mass 424.57560
Monoisotopic Mass 424.27259
InChI InChI=1S/C26H36N2O3/c1-20(2)26(19-27,22-11-12-24(30-5)25(18-22)31-6)14-8-15-28(3)16-13-21-9-7-10-23(17-21)29-4/h7,9-12,17-18,20H,8,13-16H2,1-6H3
SMILES COc1cccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)c1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Application(s): anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
vasodilator agent
A drug used to cause dilation of the blood vessels.
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ChEBI Ontology
Outgoing devapamil (CHEBI:34673) has role anti-arrhythmia drug (CHEBI:38070)
devapamil (CHEBI:34673) has role calcium channel blocker (CHEBI:38215)
devapamil (CHEBI:34673) has role vasodilator agent (CHEBI:35620)
devapamil (CHEBI:34673) is a aromatic ether (CHEBI:35618)
devapamil (CHEBI:34673) is a nitrile (CHEBI:18379)
devapamil (CHEBI:34673) is a tertiary amino compound (CHEBI:50996)
INNs Sources
devapamil ChemIDplus
devapamilo ChemIDplus
devapamilum ChemIDplus
Synonym Source
2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-((m-methoxyphenethyl)methylamino)valeronitrile ChemIDplus
Manual Xrefs Databases
Devapamil Wikipedia
US2003064085 Patent
US6344461 Patent
View more database links
Registry Numbers Types Sources
8796407 Reaxys Registry Number Reaxys
92302-55-1 CAS Registry Number KEGG COMPOUND
92302-55-1 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1652439 PubMed citation Europe PMC
8937723 PubMed citation Europe PMC
Last Modified
04 June 2013