CHEBI:34648 - clofibric acid

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ChEBI Name clofibric acid
ChEBI ID CHEBI:34648
Definition A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Johnny Lloyd
Secondary ChEBI IDs CHEBI:73161
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Formula C10H11ClO3
Net Charge 0
Average Mass 214.64524
Monoisotopic Mass 214.040
InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)
InChIKey TXCGAZHTZHNUAI-UHFFFAOYSA-N
SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): PPARalpha agonist
A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha.
marine xenobiotic metabolite
Any metabolite produced by metabolism of a xenobiotic compound in marine macro- and microorganisms.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
herbicide
A substance used to destroy plant pests.
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ChEBI Ontology
Outgoing clofibric acid (CHEBI:34648) has functional parent isobutyric acid (CHEBI:16135)
clofibric acid (CHEBI:34648) has role anticholesteremic drug (CHEBI:35821)
clofibric acid (CHEBI:34648) has role antilipemic drug (CHEBI:35679)
clofibric acid (CHEBI:34648) has role antineoplastic agent (CHEBI:35610)
clofibric acid (CHEBI:34648) has role herbicide (CHEBI:24527)
clofibric acid (CHEBI:34648) has role marine xenobiotic metabolite (CHEBI:83399)
clofibric acid (CHEBI:34648) has role PPARα agonist (CHEBI:70782)
clofibric acid (CHEBI:34648) is a aromatic ether (CHEBI:35618)
clofibric acid (CHEBI:34648) is a monocarboxylic acid (CHEBI:25384)
clofibric acid (CHEBI:34648) is a monochlorobenzenes (CHEBI:83403)
Incoming clofibrate (CHEBI:3750) has functional parent clofibric acid (CHEBI:34648)
IUPAC Name
2-(4-chlorophenoxy)-2-methylpropanoic acid
INNs Sources
acide clofibrique ChemIDplus
acido clofibrico ChemIDplus
acidum clofibricum ChemIDplus
clofibric acid ChemIDplus
Synonyms Sources
2-(4-Chlorophenoxy)-2-methylpropionic acid ChemIDplus
2-(p-Chlorophenoxy)-2-methylpropionic acid ChemIDplus
2-(p-Chlorophenoxy)isobutyric acid ChemIDplus
4-CPIB NIST Chemistry WebBook
Acide (p-chlorophenoxy)-2 methyl-2 propionique ChemIDplus
α-(4-chlorophenoxy)-α-methylpropionic acid NIST Chemistry WebBook
α-(p-chlorophenoxy)isobutyric acid NIST Chemistry WebBook
Chlorfibrinic acid ChemIDplus
Chlorofibrinic acid ChemIDplus
Chlorophibrinic acid ChemIDplus
Clofibrate free acid ChemIDplus
Clofibric acid KEGG COMPOUND
Clofibrinsäure ChemIDplus
CPIB NIST Chemistry WebBook
PCIB NIST Chemistry WebBook
PCPIB NIST Chemistry WebBook
Manual Xrefs Databases
2940 PPDB
695 DrugCentral
C13700 KEGG COMPOUND
clofibric%20acid Alan Wood's Pesticides
Clofibric_acid Wikipedia
D07723 KEGG DRUG
LSM-2427 LINCS
View more database links
Registry Numbers Types Sources
1874067 Beilstein Registry Number Beilstein
1874067 Reaxys Registry Number Reaxys
882-09-7 CAS Registry Number NIST Chemistry WebBook
882-09-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
16442995 PubMed citation Europe PMC
17431116 PubMed citation Europe PMC
23062606 PubMed citation Europe PMC
23135717 PubMed citation Europe PMC
23352585 PubMed citation Europe PMC
7320112 PubMed citation Europe PMC
8944746 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comments
2014-10-29 Metabolite of Clofibrate
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag