CHEBI:32293 - verteporfin

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name verteporfin
Definition An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): autophagy inhibitor
Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
Application(s): photosensitizing agent
A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing verteporfin (CHEBI:32293) has part (2R,21S)-8-ethenyl-21,22-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-13-propanoic acid (CHEBI:60775)
verteporfin (CHEBI:32293) has part (2R,21S)8-ethenyl-21,22-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-17-propanoic acid (CHEBI:60778)
verteporfin (CHEBI:32293) has part (2S,21R)-8-ethenyl-21,22-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-17-propanoic acid (CHEBI:60779)
verteporfin (CHEBI:32293) has part (2S,21R)-8-ethenyl-21,22-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-13-propanoic acid (CHEBI:60776)
verteporfin (CHEBI:32293) has role antineoplastic agent (CHEBI:35610)
verteporfin (CHEBI:32293) has role autophagy inhibitor (CHEBI:88230)
verteporfin (CHEBI:32293) has role photosensitizing agent (CHEBI:47868)
verteporfin (CHEBI:32293) is a mixture (CHEBI:60004)
INN Source
verteporfin ChemIDplus
Synonyms Sources
trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester ChEBI
trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester ChEBI
trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester ChEBI
trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester ChEBI
Brand Name Source
Visudyne ChemIDplus
Manual Xrefs Databases
DB00460 DrugBank
View more database links
Registry Numbers Types Sources
129497-78-5 CAS Registry Number KEGG DRUG
129497-78-5 CAS Registry Number ChemIDplus
13501128 Reaxys Registry Number Reaxys
13501141 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
25494214 PubMed citation Europe PMC
26361148 PubMed citation Europe PMC
26443705 PubMed citation Europe PMC
Last Modified
15 October 2015