CHEBI:32173 - suxibuzone

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ChEBI Name suxibuzone
Definition A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C24H26N2O6
Net Charge 0
Average Mass 438.47300
Monoisotopic Mass 438.179
InChI InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)
SMILES CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c1ccccc1)c1ccccc1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): antirheumatic drug
A drug used to treat rheumatoid arthritis.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
peripheral nervous system drug
A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
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ChEBI Ontology
Outgoing suxibuzone (CHEBI:32173) has role antirheumatic drug (CHEBI:35842)
suxibuzone (CHEBI:32173) has role non-narcotic analgesic (CHEBI:35481)
suxibuzone (CHEBI:32173) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
suxibuzone (CHEBI:32173) has role peripheral nervous system drug (CHEBI:49110)
suxibuzone (CHEBI:32173) has role prodrug (CHEBI:50266)
suxibuzone (CHEBI:32173) is a hemisuccinate (CHEBI:138979)
suxibuzone (CHEBI:32173) is a monocarboxylic acid (CHEBI:25384)
suxibuzone (CHEBI:32173) is a pyrazolidines (CHEBI:38312)
4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
INNs Sources
suxibuzona ChemIDplus
suxibuzone WHO MedNet
suxibuzone KEGG DRUG
suxibuzonum ChemIDplus
Synonyms Sources
4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate ChemIDplus
4-Hydroxymethylbutazolidine hemisuccinate ChemIDplus
Manual Xrefs Databases
1815 VSDB
2547 DrugCentral
HMDB0042019 HMDB
Suxibuzone Wikipedia
View more database links
Registry Numbers Types Sources
27470-51-5 CAS Registry Number KEGG DRUG
27470-51-5 CAS Registry Number ChemIDplus
904563 Beilstein Registry Number Beilstein
904563 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10505957 PubMed citation Europe PMC
19927590 PubMed citation Europe PMC
20037965 PubMed citation Europe PMC
3425858 PubMed citation Europe PMC
6345427 PubMed citation Europe PMC
7097505 PubMed citation Europe PMC
7452452 PubMed citation Europe PMC
8230399 PubMed citation Europe PMC
IND44395503 Agricola citation Europe PMC
Last Modified
09 November 2017