CHEBI:32124 - secobarbital sodium

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name secobarbital sodium
ChEBI ID CHEBI:32124
Definition The monosodium salt of secobarbital.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Application(s): anaesthesia adjuvant
Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing secobarbital sodium (CHEBI:32124) has part secobarbital (1−) (CHEBI:60810)
secobarbital sodium (CHEBI:32124) has role anaesthesia adjuvant (CHEBI:60807)
secobarbital sodium (CHEBI:32124) has role GABA modulator (CHEBI:50268)
secobarbital sodium (CHEBI:32124) has role sedative (CHEBI:35717)
secobarbital sodium (CHEBI:32124) is a organic sodium salt (CHEBI:38700)
IUPAC Name
sodium 2,4,6-trioxo-5-(pentan-2-yl)-5-(prop-2-en-1-yl)tetrahydro-2H-pyrimidin-1-ide
Synonyms Sources
secobarbitone sodium ChemIDplus
sodium 5-allyl-5-(1-methylbutyl)barbiturate ChemIDplus
sodium secobarbital ChemIDplus
Manual Xrefs Databases
D01310 KEGG DRUG
DB00418 DrugBank
View more database links
Registry Numbers Types Sources
309-43-3 CAS Registry Number ChemIDplus
309-43-3 CAS Registry Number KEGG DRUG
5369275 Reaxys Registry Number Reaxys
Last Modified
13 December 2010
General Comment
2010-12-13 Secobarbital sodium is a barbiturate derivative drug possessing anaesthetic, anticonvulsant, sedative and hypnotic properties. Formerly used as a hypnotic for the short-term management of insomnia and as premedication in anaesthetic procedures, it has been largely replaced by other drugs.