CHEBI:32016 - pirfenidone

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name pirfenidone
ChEBI ID CHEBI:32016
Definition A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C12H11NO
Net Charge 0
Average Mass 185.22180
Monoisotopic Mass 185.084
InChI InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey ISWRGOKTTBVCFA-UHFFFAOYSA-N
SMILES Cc1ccc(=O)n(c1)-c1ccccc1
Roles Classification
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing pirfenidone (CHEBI:32016) has role antipyretic (CHEBI:35493)
pirfenidone (CHEBI:32016) has role non-narcotic analgesic (CHEBI:35481)
pirfenidone (CHEBI:32016) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
pirfenidone (CHEBI:32016) is a pyridone (CHEBI:38183)
IUPAC Name
5-methyl-1-phenylpyridin-2(1H)-one
INNs Sources
pirfenidona ChemIDplus
pirfenidone ChemIDplus
pirfenidone KEGG DRUG
pirfenidonum ChemIDplus
Synonyms Sources
AMR 69 ChemIDplus
AMR-69 ChemIDplus
Pirfenidone Deprecated term KEGG COMPOUND
Brand Name Source
Esbriet KEGG DRUG
Manual Xrefs Databases
4224 DrugCentral
D01583 KEGG DRUG
LSM-4190 LINCS
Pirfenidone Wikipedia
View more database links
Registry Numbers Types Sources
1526549 Reaxys Registry Number Reaxys
1526549 Beilstein Registry Number ChemIDplus
53179-13-8 CAS Registry Number ChemIDplus
53179-13-8 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
25432946 PubMed citation Europe PMC
25459156 PubMed citation Europe PMC
25542603 PubMed citation Europe PMC
25593606 PubMed citation Europe PMC
25596380 PubMed citation Europe PMC
25604027 PubMed citation Europe PMC
25624597 PubMed citation Europe PMC
25639750 PubMed citation Europe PMC
25678074 PubMed citation Europe PMC
25691376 PubMed citation Europe PMC
25726556 PubMed citation Europe PMC
25727967 PubMed citation Europe PMC
25738437 PubMed citation Europe PMC
Last Modified
22 February 2017