CHEBI:31900 - neticonazole hydrochloride

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name neticonazole hydrochloride
Definition A hydrochloride resulting from the formal reaction of equimolar amounts of neticonazole and hydrogen chloride. An inhibitor of P450-dependent C-14α-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan as an antifungal drug for the treatment of superficial skin infections.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C17H23ClN2OS
Net Charge 0
Average Mass 338.897
Monoisotopic Mass 338.12196
InChI InChI=1S/C17H22N2OS.ClH/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19;/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3;1H/b16-13+;
Roles Classification
Biological Role(s): antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via imidazole antifungal drug )
(via conazole antifungal drug )
EC (sterol 14alpha-demethylase) inhibitor
An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC (sterol 14alpha-demethylase).
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
(via imidazole antifungal agent )
(via conazole antifungal agent )
ergosterol biosynthesis inhibitor
Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.
(via conazole antifungal agent )
Application(s): antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via imidazole antifungal drug )
(via conazole antifungal drug )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing neticonazole hydrochloride (CHEBI:31900) has part neticonazole(1+) (CHEBI:141384)
neticonazole hydrochloride (CHEBI:31900) has role antifungal drug (CHEBI:86327)
neticonazole hydrochloride (CHEBI:31900) has role EC (sterol 14α-demethylase) inhibitor (CHEBI:77884)
neticonazole hydrochloride (CHEBI:31900) is a conazole antifungal drug (CHEBI:87071)
neticonazole hydrochloride (CHEBI:31900) is a hydrochloride (CHEBI:36807)
neticonazole hydrochloride (CHEBI:31900) is a imidazole antifungal drug (CHEBI:87069)
1-{(E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazol-3-ium chloride
1-{(E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole hydrochloride
Synonyms Sources
1-{(E)-2-(methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazol-3-ium chloride IUPAC
1-{(E)-2-(methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole hydrochloride IUPAC
Manual Xrefs Databases
1902 DrugCentral
View more database links
Registry Numbers Types Sources
130773-02-3 CAS Registry Number ChemIDplus
5366849 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
11516941 PubMed citation Europe PMC
19942790 PubMed citation Europe PMC
8734665 PubMed citation Europe PMC
9330830 PubMed citation Europe PMC
Last Modified
24 July 2018