CHEBI:31625 - fluorometholone

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ChEBI Name fluorometholone
Definition A member of the class of glucocorticoids that is Δ1-progesterone substituted at positions 11β and 17 by hydroxy groups, at position 6α by a methyl group and at position 9 by a fluoro group. Used for the treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H29FO4
Net Charge 0
Average Mass 376.46170
Monoisotopic Mass 376.20499
InChI InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]2(C)C=CC(=O)C=C12
Roles Classification
Biological Role(s): hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
Application(s): anti-inflammatory drug
A substance that reduces or suppresses inflammation.
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ChEBI Ontology
Outgoing fluorometholone (CHEBI:31625) has functional parent Δ1-progesterone (CHEBI:34073)
fluorometholone (CHEBI:31625) has role anti-inflammatory drug (CHEBI:35472)
fluorometholone (CHEBI:31625) is a 11β-hydroxy steroid (CHEBI:35346)
fluorometholone (CHEBI:31625) is a 17α-hydroxy steroid (CHEBI:35342)
fluorometholone (CHEBI:31625) is a 20-oxo steroid (CHEBI:36885)
fluorometholone (CHEBI:31625) is a 3-oxo-Δ14-steroid (CHEBI:77166)
fluorometholone (CHEBI:31625) is a fluorinated steroid (CHEBI:50830)
fluorometholone (CHEBI:31625) is a glucocorticoid (CHEBI:24261)
fluorometholone (CHEBI:31625) is a tertiary α-hydroxy ketone (CHEBI:139592)
Incoming fluorometholone acetate (CHEBI:78354) has functional parent fluorometholone (CHEBI:31625)
INNs Sources
fluorométholone DrugBank
fluorometholone KEGG DRUG
fluorometholonum DrugBank
fluorometolona DrugBank
Synonyms Sources
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione ChemIDplus
Fluorometholon DrugBank
Brand Names Sources
Fluor-op KEGG DRUG
Manual Xrefs Databases
1208 DrugCentral
DB00324 DrugBank
Fluorometholone Wikipedia
HMDB0014469 HMDB
View more database links
Registry Numbers Types Sources
3172388 Reaxys Registry Number Reaxys
426-13-1 CAS Registry Number KEGG DRUG
426-13-1 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
22821643 PubMed citation Europe PMC
23023407 PubMed citation Europe PMC
23225837 PubMed citation Europe PMC
23429038 PubMed citation Europe PMC
23865053 PubMed citation Europe PMC
24074291 PubMed citation Europe PMC
24227962 PubMed citation Europe PMC
24493163 PubMed citation Europe PMC
Last Modified
07 February 2018