CHEBI:31403 - cinnarizine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name cinnarizine
ChEBI ID CHEBI:31403
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C26H28N2
Net Charge 0
Average Mass 368.51400
Monoisotopic Mass 368.225
InChI InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
InChIKey DERZBLKQOCDDDZ-JLHYYAGUSA-N
SMILES C1CN(CCN1C\C=C\c1ccccc1)C(c1ccccc1)c1ccccc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application(s): antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
anti-allergic agent
A drug used to treat allergic reactions.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing cinnarizine (CHEBI:31403) has role anti-allergic agent (CHEBI:50857)
cinnarizine (CHEBI:31403) has role antiemetic (CHEBI:50919)
cinnarizine (CHEBI:31403) has role calcium channel blocker (CHEBI:38215)
cinnarizine (CHEBI:31403) has role H1-receptor antagonist (CHEBI:37955)
cinnarizine (CHEBI:31403) has role histamine antagonist (CHEBI:37956)
cinnarizine (CHEBI:31403) has role muscarinic antagonist (CHEBI:48876)
cinnarizine (CHEBI:31403) is a N-alkylpiperazine (CHEBI:46845)
IUPAC Name
1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
INNs Sources
cinarizina WHO MedNet
cinnarizine WHO MedNet
cinnarizine COMe
cinnarizinum WHO MedNet
Synonyms Sources
1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine ChemIDplus
1-Benzhydryl-4-cinnamylpiperazin ChemIDplus
1-Cinnamyl-4-(diphenylmethyl)piperazine ChemIDplus
Manual Xrefs Databases
654 DrugCentral
Cinnarizine Wikipedia
D01295 KEGG DRUG
DB00568 DrugBank
US2882271 Patent
View more database links
Registry Numbers Types Sources
298-57-7 CAS Registry Number ChemIDplus
626121 Beilstein Registry Number Beilstein
Last Modified
22 February 2017