CHEBI:31401 - cilostazol

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ChEBI Name cilostazol
ChEBI ID CHEBI:31401
Definition A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substiuted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:150440
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Formula C20H27N5O2
Net Charge 0
Average Mass 369.46070
Monoisotopic Mass 369.216
InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
InChIKey RRGUKTPIGVIEKM-UHFFFAOYSA-N
SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Roles Classification
Biological Role(s): EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor
An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Application(s): anticoagulant
An agent that prevents blood clotting.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
bronchodilator agent
An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
vasodilator agent
A drug used to cause dilation of the blood vessels.
fibrin modulating drug
A drug that affects the function of fibrin in blood coagulation.
platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
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ChEBI Ontology
Outgoing cilostazol (CHEBI:31401) has role anticoagulant (CHEBI:50249)
cilostazol (CHEBI:31401) has role bronchodilator agent (CHEBI:35523)
cilostazol (CHEBI:31401) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568)
cilostazol (CHEBI:31401) has role fibrin modulating drug (CHEBI:48676)
cilostazol (CHEBI:31401) has role neuroprotective agent (CHEBI:63726)
cilostazol (CHEBI:31401) has role platelet aggregation inhibitor (CHEBI:50427)
cilostazol (CHEBI:31401) has role vasodilator agent (CHEBI:35620)
cilostazol (CHEBI:31401) is a lactam (CHEBI:24995)
cilostazol (CHEBI:31401) is a tetrazoles (CHEBI:35689)
IUPAC Name
6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydroquinolin-2(1H)-one
INNs Sources
cilostazol ChemIDplus
cilostazolum ChemIDplus
Synonyms Sources
3,4-dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinone ChemIDplus
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone ChemIDplus
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril ChemIDplus
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-1H-quinolin-2-one ChEMBL
Manual Xrefs Databases
1939 VSDB
644 DrugCentral
BE878548 Patent
Cilostazol Wikipedia
D01896 KEGG DRUG
DB01166 DrugBank
LSM-3491 LINCS
US4277479 Patent
View more database links
Registry Numbers Types Sources
3632017 Beilstein Registry Number Beilstein
73963-72-1 CAS Registry Number KEGG DRUG
73963-72-1 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
17500510 PubMed citation ChEMBL
9873372 PubMed citation ChEMBL
Last Modified
22 February 2017
General Comment
2011-03-18 A phosphodiesterase inhibitor with antiplatelet and vasodilating activity, cilostazol is used in the management of the symptoms of peripheral vascular disease, particularly pain in the legs which develops during exercise but disappears at rest.